2-VALERYLOXYBENZOIC ACID Struktur

2-VALERYLOXYBENZOIC ACID

Bezeichnung:2-VALERYLOXYBENZOIC ACID

CAS-Nr64206-54-8

Englisch Name:2-VALERYLOXYBENZOIC ACID

CBNumberCB8270272

SummenformelC12H14O4

Molgewicht222.24

MOL-Datei64206-54-8.mol

2-VALERYLOXYBENZOIC ACID physikalisch-chemischer Eigenschaften

Schmelzpunkt	86-87 °C(lit.)
Siedepunkt	357.6±25.0 °C(Predicted)
Dichte	1.175±0.06 g/cm3(Predicted)
storage temp.	Room temperature
Löslichkeit	DMSO: 24 mL/mL
pka	3.01±0.36(Predicted)
Aggregatzustand	A crystalline solid
Farbe	white

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3

Gefahreninformationscode (GHS)

2-VALERYLOXYBENZOIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Valeryl salicylate is a selective inhibitor of Cox-1.
Definition
ChEBI: A valerate ester that is salicylic acid in which the phenolic hydrogen is replaced by a valeryl (pentanoyl) group.
Biologische Aktivität
valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively [1].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively. in cos-1 cells expressing either cox-1 or -2, 500 μm of valeroyl salicylate inhibited human cox-1 and -2 by 85% and 15%, respectively. the half-lives for inactivation of human recombinant cox-1 in the presence of 500 μm valeroyl salicylate was 12 minutes [2].
Einzelnachweise
[1]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[2]. bhattacharyya dk, lecomte m, dunn j, et al. selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. arch biochem biophys. 1995 feb 20;317(1):19-24.

2-VALERYLOXYBENZOIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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