PPARγ Ligand Pack

PPARγ Ligand Pack Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  The Cayman PPARγ Ligand Pack contains a combination of frequently used ligands for the nuclear PPARγ. Each kit contains Ciglitazone, the first characterized member of the thiazolidinedione (TZD) class that binds to the PPARγ ligand-binding domain with an EC₅₀ value of 3.0 μM. Rosiglitazone, a key reference TZD also called BRL 49653, its more potent structural homolog MCC-555, and PPARγ-1-selective pioglitazone are other PPARγ agonists provided. Also included is Troglitazone (Resulin™), another TZD; it was withdrawn from human therapeutic use due to hepatotoxicity. Also in this assortment is 15-deoxy-Δ^12,14-Prostaglandin J₂, a potent PPARγ ligand derived from PGD₂. The actions of all of these compounds can be antagonized by the selective PPARγ antagonist, GW 9662, which is also in the kit.

PPARγ Ligand Pack Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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