TRICHOSTATIN A

Bezeichnung:TRICHOSTATIN A

CAS-Nr58880-19-6

Englisch Name:TRICHOSTATIN A

CBNumberCB8257301

SummenformelC17H22N2O3

Molgewicht302.37

MOL-Datei58880-19-6.mol

TRICHOSTATIN A physikalisch-chemischer Eigenschaften

Schmelzpunkt	140-143℃
alpha	D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
Dichte	1.139
Brechungsindex	136 ° (C=0.3, MeOH)
storage temp.	-20°C
Löslichkeit	ethanol: 1 mg/mL
pka	8.93±0.23(Predicted)
Aggregatzustand	Off-white lyophilized solid
Farbe	Tan
Merck	14,9649
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey	ZWGICMNKJBUOHG-RCXLNATQSA-N

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21/22-36/37/38-43
S-Sätze:	26-36
RIDADR	NA 1993 / PGIII
WGK Germany	3
RTECS-Nr.	MI5215000
HS Code	29280000

Gefahreninformationscode (GHS)

TRICHOSTATIN A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.
Chemische Eigenschaften
Solid
Verwenden
Trichostatin A, ready-made solution has been used:
- as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
- to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
- to treat cells for the HDAC inhibition experiments
Verwenden
Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity
Verwenden
Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.
Definition
ChEBI: Trichostatin A is an antibiotic antifungal agent, a trichostatin and a hydroxamic acid. It has a role as a bacterial metabolite, a geroprotector and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is functionally related to a (R)-trichostatic acid.
Allgemeine Beschreibung
Trichostatin A is a compound of primary hydroxamic acid.
Biologische Aktivität
Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.
Biochem/physiol Actions
Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.
Lager
-20°C (desiccate)
Einzelnachweise
1) Yoshida et al. (1990), Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A ; J. Biol. Chem., 265 17174 2) Futamura et al. (1995), Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells; Oncogene, 10 1119 3) Durcova-Hills et al. (2008), Reprogramming Primordial Germ Cells into Pluripotent Stem Cells; PLoS-One, 3 e3531

TRICHOSTATIN A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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