L-Ribose

Bezeichnung:L-Ribose

CAS-Nr24259-59-4

Englisch Name:L-Ribose

CBNumberCB8256607

SummenformelC5H10O5

Molgewicht150.13

MOL-Datei24259-59-4.mol

Synonyma

L-Ribose

L-Ribose physikalisch-chemischer Eigenschaften

Schmelzpunkt	81-82 °C(lit.)
alpha	20 º (c=2,water)
Siedepunkt	191.65°C (rough estimate)
Dichte	1.1897 (rough estimate)
Brechungsindex	20 ° (C=1, H2O)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Methanol (Slightly), Water (Slightly)
Aggregatzustand	Solid
pka	12.22(at 25℃)
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in water (100 mg/ml).
BRN	1723084
Stabilität	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS Datenbank	24259-59-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38-37-36-36/38
S-Sätze:	24/25-36-26-37/39
WGK Germany	3
RTECS-Nr.	246-110-4
F	3-10
HS Code	29400000

Gefahreninformationscode (GHS)

L-Ribose Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R37:Reizt die Atmungsorgane.
R36:Reizt die Augen.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
white crystals or powder
Verwenden
It is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate.
Verwenden
L-[1-13C]ribose is a compound useful in organic synthesis.
Definition
ribose: A monosaccharide, C₅H₁₀O₅, rarely occurring free in nature but important as a component of RNA (ribonucleic acid). Its derivative deoxyribose, C₅H₁₀O₄, is equally important as a constituent of DNA (deoxyribonucleic acid), which carries the genetic code in chromosomes.
Definition
A monosaccharide; a component of RNA.
Biosynthese
L-ribose is the enantiomer of D-ribose, which occurs naturally. It is a building block of many novel nucleotide analogue anti-viral drugs. Bio-production of L-ribose relies on a two-step reaction: (i) conversion of L-arabinose to L-ribulose by the catalytic action of L-arabinose isomerase (L-AI) and (ii) conversion of L-ribulose to L-ribose by the catalytic action of L-ribose isomerase (L-RI, EC 5.3.1.B3) or mannose-6-phosphate isomerase (MPI, EC 5.3.1.8, alternately named as phosphomannose isomerase). Among the two enzymes, L-RI is a rare enzyme discovered in 1996 by Professor Izumori's group, whereas MPI is an essential enzyme in metabolic pathways in humans and microorganisms[1].
Synthese
A method for converting inexpensive, naturally occurring D-ribose into L-ribose is by interconverting the hydroxy group at Cl and the hydroxymethyl group at C5. L-Ribose is prepared from D-ribose by (a) forming a hydroxy-protected D-ribose, (b) reducing the hydroxy-protected D-ribose to a protected tetrol, (c) converting the tetrol to a tetraester, such as a tetraacetate; (d) hydrolyzing the protecting group to form a hydroxymethyl tetraester; (e) oxidizing the hydroxymethyl group to form a tetraester aldehyde; and (f) hydrolysing the ester groups to yield L-ribose.
Einzelnachweise
[1] M. Helanto. “Biotechnological production of l-ribose from l-arabinose.” Applied Microbiology and Biotechnology 83 1 (2009): 77–83.

L-Ribose Upstream-Materialien And Downstream Produkte

L-Ribose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

24259-59-4, L-Ribose Verwandte Suche:

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