MYRISTOYL-DL-CARNITINE CHLORIDE Struktur

MYRISTOYL-DL-CARNITINE CHLORIDE

Bezeichnung:MYRISTOYL-DL-CARNITINE CHLORIDE

CAS-Nr14919-38-1

Englisch Name:MYRISTOYL-DL-CARNITINE CHLORIDE

CBNumberCB8254739

SummenformelC21H42ClNO4

Molgewicht408.02

MOL-Datei14919-38-1.mol

MYRISTOYL-DL-CARNITINE CHLORIDE physikalisch-chemischer Eigenschaften

storage temp.	−20°C
Löslichkeit	<10.2mg/ml in H2O
Aggregatzustand	solid
Farbe	White
Wasserlöslichkeit	Soluble to 25 mM in water

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-43
S-Sätze:	36/37
WGK Germany	3

MYRISTOYL-DL-CARNITINE CHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Verwenden
(+/-)-Myristoylcarnitine Chloride is a homolog of Acetylcarnitine Chloride (A171990), and an intermediate in lipid metabolism.
Biologische Aktivität
(±)-myristoylcarnitine chloride is an agonist for cholinergic and a homolog of acetylcarnitine chloride (cat no. b6273).acetylcholine receptor (achr) is an integral membrane protein receptor for acetylcholine. there are two kinds of achrs: nicotinic acetylcholine receptors and muscarinic acetylcholine receptors.(±)-myristoylcarnitine chloride is a cholinergic agonist and an intermediate in lipid metabolism [1]. in retinal ganglion cells, acetylcarnitine and acetylcholine inhibited gabaergic responses to exogenous gaba and gabaergic inhibitory postsynaptic currents [2].in dogs with coronary ligation, (-)-carnitine chloride (lcc) (300 mg/kg) and acetyl (-)-carnitine chloride (alcc) (300 mg/kg) inhibited the ventricular arrhythmia. also, lcc and alcc improved oxidative phosphorylation rate and the mitochondrial function [1]. in the mouse hot plate test, acetyl-l-carnitine (alcar) (100 mg/kg) exhibited analgesia. while, u-73122 and neomycin (the phospholipase c (plc) inhibitors) blocked the increase of the pain threshold induced by alcar. licl that impairing phosphatidylinositol synthesis antagonized the antinociception in a dose-dependent way. pma and pdbu (pkc activators) blocked the increase of the pain threshold in a dose-dependent way. these results suggested that alcar analgesia required the participation of the plc-ip3 pathway [3].

MYRISTOYL-DL-CARNITINE CHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

14919-38-1, MYRISTOYL-DL-CARNITINE CHLORIDE Verwandte Suche:

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