N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H400：Sehr giftig für Wasserorganismen.

• Sicherheit

  P273：Freisetzung in die Umwelt vermeiden.

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  PtdIns-(3,4,5)-P₃ (PIP₃) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP₃ is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP₃/Akt PH domain binding with an IC₅₀ value of 31 μM. PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC₅₀ = 37 μM).

• Verwenden

  PIT 1 is an apoptosis inducing selective PIP3 antagonist.

• Einzelnachweise

  1) Maio?et al.?(2010),?Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PI3) binding to pleckstrin homology domains; Proc. Natl. Acad. Sci. USA,?107?20126 2) McNamare and Degterev?(2011),?Small-molecule inhibitor of the PI3K signaling network; Future Med. Chem.,?3?549

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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