(6-Chloropyrazin-2-yl)acetic acid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H332：Gesundheitsschädlich bei Einatmen.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

(6-Chloropyrazin-2-yl)acetic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  930798-26-8

  

  930798-25-7

  Step 2: To a 20L three-necked round-bottomed flask was added deionized water (9L) and sodium hydroxide (900g, 22.50 mol, 3.07 eq.) in batches and stirred well. Under stirring, 1,3-diethyl 2-(6-chloropyrazin-2-yl)malonate (2 kg, 1.00 eq., crude) was added slowly and dropwise while the reaction temperature was controlled to be lower than 10°C. The reaction was carried out at a temperature below 10°C. The reaction was carried out at a temperature below 10°C. After completion of the reaction, the mixture was stirred at room temperature overnight and then cooled to 0°C. The pH of the reaction solution was adjusted to 9-10 with 37% hydrochloric acid and subsequently extracted with ethyl acetate (3 x 2 L). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was washed with petroleum ether (1 x 1.5 L) and methyl tert-butyl ether (1 x 1.5 L), dried again with anhydrous sodium sulfate and concentrated under reduced pressure to give 463.6 g (37% yield) of 2-(6-chloropyrazin-2-yl)acetic acid as a yellow solid.

• Einzelnachweise

  [1] Patent: WO2007/35153, 2007, A1. Location in patent: Page/Page column 4-5
  [2] Patent: WO2007/35154, 2007, A1. Location in patent: Page/Page column 28-29
  [3] Patent: US2015/31674, 2015, A1. Location in patent: Paragraph 0325; 0322

(6-Chloropyrazin-2-yl)acetic acid Upstream-Materialien And Downstream Produkte

(6-Chloropyrazin-2-yl)acetic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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