2',5'-Dihydroxyacetophenon

Bezeichnung:2',5'-Dihydroxyacetophenon

CAS-Nr490-78-8

Englisch Name:2',5'-Dihydroxyacetophenone

CBNumberCB8221168

SummenformelC8H8O3

Molgewicht152.15

MOL-Datei490-78-8.mol

Synonyma

2',5'-Dihydroxyacetophenon

2',5'-Dihydroxyacetophenon physikalisch-chemischer Eigenschaften

Schmelzpunkt	204-206 °C(lit.)
Siedepunkt	234.6°C (rough estimate)
Dichte	1.2143 (rough estimate)
Brechungsindex	1.4447 (estimate)
storage temp.	Store below +30°C.
Löslichkeit	dioxane: 50 mg/mL, clear
Aggregatzustand	Crystals or Crystalline Powder
pka	9.86±0.18(Predicted)
Farbe	Yellow to yellow-green
Wasserlöslichkeit	insoluble
BRN	637903
InChIKey	WLDWSGZHNBANIO-UHFFFAOYSA-N
LogP	1.274 (est)
CAS Datenbank	490-78-8(CAS DataBase Reference)
NIST chemische Informationen	Ethanone, 1-(2,5-dihydroxyphenyl)-(490-78-8)
EPA chemische Informationen	Ethanone, 1-(2,5-dihydroxyphenyl)- (490-78-8)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	AM7700000
Hazard Note	Irritant
TSCA	Yes
HS Code	29145000

Gefahreninformationscode (GHS)

2',5'-Dihydroxyacetophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2',5'-Dihydroxyacetophenone is a natural phenolic compound that is found in many plants. It has been shown to have anti-inflammatory properties through its ability to inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin 1 beta.
Chemische Eigenschaften
yellow to yellow-green crystals or
Verwenden
1-(2,5-Dihydroxyphenyl)ethanone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.
Verwenden
2',5'-Dihydroxyacetophenone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.
synthetische
Preparation by Fries rearrangement of hydroquinone diacetate,
with aluminium chloride(91%) (76%)(63–77%) (55–60%)
with zinc chloride in refluxing acetic acid (quantitative yield)
with boron trifluoride etherate in benzene at reflux (65%).
Application
2',5'-Dihydroxyacetophenone inhibits the formation of reactive oxygen species and nitric oxide in rat neutrophils. It also has the ability to reduce oxidative stress by scavenging free radicals and inhibiting lipid peroxidation. The underlying mechanism for these effects is not fully understood but may be due to its ability to act as a substrate for matrix-assisted laser desorption ionization (MALDI). This means that it can react with protocatechuic acid molecules that are present in the sample preparation chamber, leading to polymerase chain reaction (PCR) amplification.
Definition
ChEBI: 2',5'-Dihydroxyacetophenone is an aromatic ketone.
Synthesis Reference(s)
The Journal of Organic Chemistry, 18, p. 1709, 1953 DOI: 10.1021/jo50018a014

2',5'-Dihydroxyacetophenone Upstream-Materialien And Downstream Produkte

2',5'-Dihydroxyacetophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

490-78-8, 2',5'-Dihydroxyacetophenone Verwandte Suche:

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