5-Amino-2,4,6-triiodoisophthaloyl dichloride

Bezeichnung:5-Amino-2,4,6-triiodoisophthaloyl dichloride

CAS-Nr37441-29-5

Englisch Name:5-Amino-2,4,6-triiodoisophthaloyl dichloride

CBNumberCB8206516

SummenformelC8H2Cl2I3NO2

Molgewicht595.73

MOL-Datei37441-29-5.mol

5-Amino-2,4,6-triiodoisophthaloyl dichloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	231°C(lit.)
Siedepunkt	566.9±50.0 °C(Predicted)
Dichte	2.826±0.06 g/cm3(Predicted)
Dampfdruck	0.018Pa at 20℃
storage temp.	Refrigerator, under inert atmosphere
Löslichkeit	Acetone (Slightly), Methanol (Very Slightly)
pka	-3.45±0.10(Predicted)
Aggregatzustand	Solid
Farbe	Yellow toDark Brown
maximale Wellenlänge (λmax)	233nm(MeOH)(lit.)
LogP	3.7 at 20℃
CAS Datenbank	37441-29-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,N
R-Sätze:	43-51/53
S-Sätze:	22-36/37-61
RIDADR	3077
HS Code	2922.49.3700
HazardClass	9
PackingGroup	III

Gefahreninformationscode (GHS)

5-Amino-2,4,6-triiodoisophthaloyl dichloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
5-Amino-2,4,6-triiodoisophthaloyl dichloride is a triiodinated compound that has been shown to bind to the receptor for asialoglycoprotein. It is used in the diagnosis of liver and kidney diseases. 5-Amino-2,4,6-triiodisophthaloyl acid dichloride is taken up by tissues and organs and causes damage to these tissues. The chloride ion binds to the molecule, making it more water soluble. The lactobionic acid residue is then cleaved off by an enzyme in the cell called beta-galactosidase. This leaves a molecule containing iodine which can be detected with a diagnostic technique such as X-ray crystallography or nuclear magnetic resonance spectroscopy.
Chemische Eigenschaften
Yellow Solid
Verwenden
5-Amino-2,4,6- triiodisophthaloyl acid dichloride is used in the preparation of trimeric X-ray contrast agents.
synthetische
5-Amino-2,4,6-triiodo-isophtalic acid (30 g, 0.054 mol), thionyl chloride (8.2 ml, 0.113 mol) and pyridine (0.2 ml) in 1 ,2 dichloroethane (20 ml) were heated to 70 ℃. A portion of thionyl chloride (15.2 ml, 0.21 mol) was added dropwise during 2 h, and the mixture was heated to 85 ℃ for 6 h. After cooling the reaction mixture to room temperature, it was poured into 300 g of ice-water. The yellow precipitate was filtered off, sucked dry and then washed with water until pH=5. The filter cake was then dried in a vacuum oven for 3 hrs. A light yellow powder was obtained as 5-Amino-2,4,6-triiodisophthaloyl acid dichloride.
Flammability and Explosibility
Not classified

5-Amino-2,4,6-triiodoisophthaloyl dichloride Upstream-Materialien And Downstream Produkte

5-Amino-2,4,6-triiodoisophthaloyl dichloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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