TCPOBOP Struktur

TCPOBOP

Bezeichnung:TCPOBOP

CAS-Nr76150-91-9

Englisch Name:TCPOBOP

CBNumberCB8155924

SummenformelC16H8Cl4N2O2

Molgewicht402.06

MOL-Datei76150-91-9.mol

TCPOBOP physikalisch-chemischer Eigenschaften

Siedepunkt	444.8±45.0 °C(Predicted)
Dichte	1.518±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: >10 mg/mL
Aggregatzustand	solid
pka	-0.52±0.10(Predicted)
Farbe	white
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
RTECS-Nr.	UT7145000

TCPOBOP Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.
Verwenden
TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.
Allgemeine Beschreibung
A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.
Biochem/physiol Actions
TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.
Einzelnachweise
1) Tzameli et al. (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR; Mol. Cell. Biol., 20 2951 2) Diwan et al. (1992) Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine; Carcinogenesis, 13 1893

TCPOBOP Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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