L-N-(N-hydroxy-2-isobutylsuccinamoyl)seryl-L-valine

L-N-(N-hydroxy-2-isobutylsuccinamoyl)seryl-L-valine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 days, BE16627B inhibited MP activity in the primary culture supernatants from synovial cells in a dose-dependent fashion without showing apparent cytotoxicity or affecting the production and secretion of MPs. Its IC50 for active collagenolysis before activation by trypsin was 25 microM.

L-N-(N-hydroxy-2-isobutylsuccinamoyl)seryl-L-valine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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