methylazoxymethanol
Bezeichnung:methylazoxymethanol
CAS-Nr590-96-5
Englisch Name:methylazoxymethanol
CBNumberCB81331514
SummenformelC2H6N2O2
Molgewicht90.08
MOL-Datei590-96-5.mol
methylazoxymethanol physikalisch-chemischer Eigenschaften
| Siedepunkt | 167.26°C (rough estimate) |
| Dichte | 1.3348 (rough estimate) |
| Brechungsindex | 1.4462 (estimate) |
| EPA chemische Informationen | Methylazoxymethanol (590-96-5) |
| RIDADR | 2810 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Giftige Stoffe Daten | 590-96-5(Hazardous Substances Data) |
| Toxizität | A naturally occurring alkylating agent that is produced by the cycad. It was found originally as the active agent formed from cycasin (methylazoxymethanol- β-D-glucoside). Ingestion of this plant by animals or humans has been associated with hepatotoxicity, carcinogenicity, and teratogenesis. MAM is an alkylating agent that is probably metabolized to diazomethane, that subsequently forms active methyl groups that methylate nucleotide bases and impair DNA and RNA synthesis. Administration of MAM during fetal life causes a microcephaly that is associated with extensive necrosis in the area normally occupied by differentiating cells and seems to result from the disruption of cell replication. Administration restricted to postnatal life has selective effects on areas that mature postnatally. Marked cerebellar lesions characterize the neuropathology observed following postnatal administration to experimental animals, with measurable but less dramatic effects on the hippocampus and olfactory bulb, two regions that undergo a significant part of their development postnatally. Behaviorally, the animals show fairly specific neurological signs related to disruption of motor function. Anatomical findings are characterized by decreased cerebellar mass, diminished numbers of cells that can be attributed to a deficit in the number of granule cells. In contrast, postnatal MAM effects on developing spinal cord are characterized by fairly specific decreases in indices of glia and myelin formation, again consistent with the mainly prenatal differentiation of this region, that is therefore spared. |