1H-Pyrazole-3-carboxamide, 4-[[3-chloro-5-(4-methyl-1-piperazinyl)benzoyl]amino]-N-cyclohexyl-

1H-Pyrazole-3-carboxamide, 4-[[3-chloro-5-(4-methyl-1-piperazinyl)benzoyl]amino]-N-cyclohexyl- Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  (rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs), vascular endothelial growth factor receptor kinases (VEGF-RTKs), and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis, while reducing the expression of MCL1, survivin, and HIF1α. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis, and may become a potential agent for inhibiting NET[1].

• Einzelnachweise

  [1] The oral multitarget tumour growth inhibitor, ZK 304709, inhibits growth of pancreatic neuroendocrine tumours in an orthotopic mouse model

1H-Pyrazole-3-carboxamide, 4-[[3-chloro-5-(4-methyl-1-piperazinyl)benzoyl]amino]-N-cyclohexyl- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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