BENZONITRILE OXIDE

BENZONITRILE OXIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Definition

  ChEBI: Benzonitrile oxide is a nitrile oxide. It is functionally related to a benzonitrile.

• synthetische

  The most widely employed methods of benzonitrile oxide(1) generation involve triethylamine-mediated dehydrohalogenation of benzhydroxamoyl chloride  (or bromide), readily accessible through chlorination of benzaldoxime, or dehydration of α-nitrotoluene with PhCNO or PhSO2Cl or ClCO2Et and a catalytic amount of Et3N (Mukaiyama reaction). A reaction of (2) with alkali metal fluorides also provides a facile quantitative generation of (1). Although (1) has been obtained as a crystalline solid, it is commonly generated in situ. Et3N almost immediately reacts with (2), and should be added very slowly to an ice-cooled solution of (2) to maintain a low stationary concentration of (1) and thereby suppress its dimerization into 3,4-diphenylfuroxan (3). Benzonitrile oxide can also be generated photochemically by irradiation of (2) and Hexabutyldistannane, or via electrochemical oxidation of benzaldoxime.

• Synthesis Reference(s)

  The Journal of Organic Chemistry, 53, p. 2468, 1988 DOI: 10.1021/jo00246a014

• Lager

  Usually prepared in situ; readily undergoes dimerization on storage; use in a fume hood.

BENZONITRILE OXIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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