CHLORISONDAMINE DIIODIDE Struktur

CHLORISONDAMINE DIIODIDE

Bezeichnung:CHLORISONDAMINE DIIODIDE

CAS-Nr69-27-2

Englisch Name:CHLORISONDAMINE DIIODIDE

CBNumberCB8118307

SummenformelC14H20Cl4N2.2Cl

Molgewicht611.94

MOL-Datei69-27-2.mol

CHLORISONDAMINE DIIODIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	258-265° (dec)
Siedepunkt	579.33°C (rough estimate)
Dichte	1.4157 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	2-8°C
Löslichkeit	H₂O: ~3.75 mg/mL
Aggregatzustand	solid
Farbe	white

Sicherheit

Kennzeichnung gefährlicher	Xn,N
R-Sätze:	22-50
S-Sätze:	60-61
WGK Germany	2

Gefahreninformationscode (GHS)

CHLORISONDAMINE DIIODIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R50:Sehr giftig für Wasserorganismen.
S-Sätze Betriebsanweisung:
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Originator
Ecolid Chloride,Ciba,US,1956
Verwenden
Biochemical probe in nicotinic receptor studies.
Verwenden
Chlorisondamine Diiodide is being used as an intracranial injection to study the localization and analysis of small drug molecules in rat brain tissue.
Manufacturing Process
50 parts by weight of 3,4,5,6-tetrachlorophthalic anhydride is added with stirring and cooling to 30 parts by volume of 2-dimethylaminoethyl amine. The mixture is heated at 170°C for 4 minutes and the oily residue then dissolved in 200 parts by volume of hot ethanol. On cooling, N-(2'- dimethylaminoethyl)-3,4,5,6-tetrachlorophthalimide separates. It crystallizes from ethanol and melts at 184°-186°C.
6 parts by weight of N-(2'-dimethylaminoethyl)-3,4,5,6-tetrachlorophthalimide is extracted continuously with 300 parts by volume of dry ether in which have been dissolved 3.1 parts by weight of lithium aluminum hydride. After 48 hours the excess lithium aluminum hydride is destroyed by cautious addition of 9 parts by volume of ethyl acetate while stirring. There is then added in succession with stirring 3 parts by volume of water, 6 parts by volume of 15% aqueous sodium hydroxide and 9 parts by volume of water. The granular precipitate of lithium and aluminum salts are filtered and washed with ether. The ether is distilled off, yielding the crude, oily 4,5,6,7-tetrachloro-2-(2'- dimethylaminoethyl)-isoindoline. The above base is dissolved in 25 parts by volume of 90% ethanol and refluxed 2 hours with 6 parts by volume of methyl iodide. 4,5,6,7-tetrachloro-2-(2'-dimethylaminoethyl)-isoindoline dimethiodide separates during the reaction. It is collected by filtration and recrystallized
from a mixture of ethanol and water; MP 244°-246°C. 4,5,6,7-tetrachloro-2-(2'-dimethylaminoethyl)-isoindoline dimethochloride is prepared by shaking an aqueous solution of the dimethiodide with an excess of freshly prepared silver chloride and evaporating to dryness the aqueous solution after removal of the silver salts. 4,5,6,7-tetrachloro-2-(2'- dimethylaminoethyl)-isoindoline dimethochloride is recrystallized from ethanolethylacetate; MP 276°-280°C.
Therapeutic Function
Antihypertensive
Biologische Aktivität
An exceptionally long lasting nicotinic antagonist (IC 50 ~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.

CHLORISONDAMINE DIIODIDE Upstream-Materialien And Downstream Produkte

CHLORISONDAMINE DIIODIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

69-27-2, CHLORISONDAMINE DIIODIDE Verwandte Suche:

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