Azatepa

Azatepa Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Azatepa,ZYF Pharm Chemical

• Verwenden

  Antineoplastic.

• Definition

  ChEBI: Azatepa is a phosphoramide.

• Manufacturing Process

  N-Ethyl-N-(1,3,4-thiadiazol-2-yl)amidophosphoryl chloride is prepared by refluxing 16.4 parts of 2-ethylamino-1,3,4-thiadiazole hydrochloride with 84 parts of phosphorus oxychloride for 6 h and then removing the excess phosphorus oxychloride by distillation under reduced pressure. The residual oil is washed with cold petroleum ether, dried and dissolved in 310 parts of dry benzene.
  The solution of N-ethyl-N-(1,3,4-thiadiazol-2-yl)amidophosphoryl chloride is added slowly at 10°C to a mixture of 9.5 parts of ethylenimine, 30.3 parts of triethylamine, and 44 parts of warm dry benzene. Agitation is continued for 2 h without cooling after which the triethylamine hydrochloride is filtered off. The benzene is distilled from the filtrate under reduced pressure, and the N,N'-diethylene-N''-ethyl-(N'-(1,3,4-thiadiazo-2-yl)phosphoramide is recrystallized from hexane, melting point 95°-96°C.

• Therapeutic Function

  Antineoplastic

Azatepa Upstream-Materialien And Downstream Produkte

Azatepa Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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