Quinupristin Struktur

Quinupristin

Bezeichnung:Quinupristin

CAS-Nr120138-50-3

Englisch Name:Quinupristin

CBNumberCB81073487

SummenformelC53H67N9O10S

Molgewicht1022.23

MOL-Datei120138-50-3.mol

Quinupristin physikalisch-chemischer Eigenschaften

Schmelzpunkt

~200°

Sicherheit

Giftige Stoffe Daten

120138-50-3(Hazardous Substances Data)

Quinupristin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Quinupristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria. Quinupristin is usually combined with another streptogramin antibiotic, dalfopristin , to produce quinupristin-dalfopristin complex , known commercially as Synercid. While both quinupristin and dalfopristin have bacteriostatic effects, they act synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria.
Verwenden
Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogrycin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
Verwenden
Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
Verwenden
Semisynthetic depsipeptide type I streptogramin. An antibacterial agent.

Quinupristin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

120138-50-3, Quinupristin Verwandte Suche:

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