Ivabradine hydrochloride

Bezeichnung:Ivabradine hydrochloride

CAS-Nr148849-67-6

Englisch Name:Ivabradine hydrochloride

CBNumberCB81006694

SummenformelC27H37ClN2O5

Molgewicht505.05

MOL-Datei148849-67-6.mol

Ivabradine hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	193-196?C
alpha	58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
storage temp.	2-8°C
Löslichkeit	H2O: ≥5mg/mL (warmed)
Aggregatzustand	powder
Farbe	white to beige
Optische Aktivität	[α]/D +5 to +9°, c = 1 in DMSO
Merck	14,5247
InChIKey	HLUKNZUABFFNQS-ZMBIFBSDSA-N
SMILES	C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl \|&1:1,r\|
CAS Datenbank	148849-67-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	N
R-Sätze:	50/53
S-Sätze:	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
HS Code	2933.79.1500

Gefahreninformationscode (GHS)

Ivabradine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) – 80% (10 mM). .
Chemische Eigenschaften
White to Off-White Solid
Originator
Servier (France)
Verwenden
angina therapeutic
Verwenden
Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent
Verwenden
Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal
Verwenden
Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT).
Definition
ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.
Trademarks
Procoralan
Biochem/physiol Actions
Ivabradine is used to treat chronic heart failure.
Clinical Use
Symptomatic treatment of chronic stable angina pectoris in patients with sinus rhythm Treatment of mild to severe chronic heart failure
Lager
Store at -20°C

Ivabradine hydrochloride Upstream-Materialien And Downstream Produkte

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