IRAK-1/4 INHIBITOR I Struktur

IRAK-1/4 INHIBITOR I

Bezeichnung:IRAK-1/4 INHIBITOR I

CAS-Nr509093-47-4

Englisch Name:IRAK-1/4 INHIBITOR I

CBNumberCB7972737

SummenformelC20H21N5O4

Molgewicht395.41

MOL-Datei509093-47-4.mol

IRAK-1/4 INHIBITOR I physikalisch-chemischer Eigenschaften

Dichte	1.40
storage temp.	2-8°C
Löslichkeit	DMSO: ≥5mg/mL
Aggregatzustand	Yellow crystalline solid
pka	11.54±0.43(Predicted)
Farbe	off-white to light yellow

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-36/37/38
S-Sätze:	26-36/37-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3

Gefahreninformationscode (GHS)

IRAK-1/4 INHIBITOR I Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Verwenden
IRAK-1/4 Inhibitor (interleukin-1 receptor-associated kinases) are important mediators in signal transduction of TIR family members. This regulation protects against the development of cancers and other diseases.
Verwenden
IRAK-1/4 inhibitor I has been used in various studies to inhibit IRAK1 in hepatoma cell lines and head and neck squamous cell carcinoma (HNSCC) cell lines.
Biologische Aktivität
irak-1-4 inhibitor i is an inhibitor of both irak-1 and irak-4 with ic50 values of 0.3μm and 0.2μm , respectively [1].il-1 receptor-associated kinases play important roles in signal transduction. there are totally four members of the iraks, they are irak-1, irak-2, irak-m and irak-4. irak-4 can activate nf-κb and mapk pathways and it is shown that the inhibition of irak-4 can be an anti-inflammatory therapy. irak-1-4 inhibitor i is an analog of an initial irak-4 inhibitor hit, which is screened out from a small molecule li brary against irak-4. with the less basic n-ethylenemorpholine moiety, irak-1-4 inhibitor i has a higher potency than other analogs. additionally, it does not show any cytotoxicity in a 72 h proliferation assay in hela cells(ed50 >30μm) [1].
Biochem/physiol Actions
IRAK1 overexpression leads to the development of head and neck squamous cell carcinoma (HNSCC). Therefore, IRAK-1/4 inhibitor I might be a potential therapeutic for HNSCC tumors. Various experimental studies states that IRAK-1/4 inhibitor might have a potential to exhibit?inhibitory effects on the nuclear factor (NF)-κB signaling pathway.
Lager
Store at -20°C
Einzelnachweise
[1] jay p. powers, shyun li, juan c. jaen, jinqian liu, nigel p. c. walker, zhulun wang and holger wesche. discovery and initial sar of inhibitors of interleukin-1 receptor-associated kinase-4. bioorganic & medicinal chemistry letters. 2006, 16: 2842–2845.

IRAK-1/4 INHIBITOR I Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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