CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P

CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  It is one of a series of AMPA modulators matergic AMPA receptors.

• Verwenden

  CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

• Allgemeine Beschreibung

  CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

• Biologische Aktivität

  AMPA receptor potentiator. Binds specifically to the agonist bound non-desensitized receptor, most likely destabilizing the desensitized receptor conformation. Enhances cognitive function in rats.

• Biochem/physiol Actions

  CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI)?in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

• Lager

  Store at +4°C

CX546 (1-(1,4-BENZODIOXAN-6-YLCARBONYL)P Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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