Alminoprofen

Bezeichnung:Alminoprofen

CAS-Nr39718-89-3

Englisch Name:alminoprofen

CBNumberCB7885929

SummenformelC13H17NO2

Molgewicht219.28

MOL-Datei39718-89-3.mol

Synonyma

Alminoprofen

Alminoprofen physikalisch-chemischer Eigenschaften

Schmelzpunkt	107°
Siedepunkt	360.1°C (rough estimate)
Dichte	1.0697 (rough estimate)
Brechungsindex	1.5100 (estimate)
storage temp.	-20°C Freezer
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	4.86±0.50(Predicted)
Farbe	Light Brown

Sicherheit

Toxizität

LD50 orally in mice: 2400 mg/kg (Dumaitre)

Gefahreninformationscode (GHS)

alminoprofen Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Alminoprofen is an arylpropionic acid analgesic/antiinflammatory agent indicated for the short term management of dental, traumatic and postpartum pain.
Originator
Labs. Dr. E. Bouchara (France)
Verwenden
Alminoprofen is a nonsteroidal antiinflammatory drugs (NSAID) of the phenylpropionic acid class. Alminoprofen maybe a useful therapeutic option in the management of immune dysfunction in rheumatoid ar thritis.
Definition
ChEBI: A substituted aniline that is ibuprofen in which the isobutyl group is replaced by a (2-methylprop-2-en-1-yl)amino group. A non-steroidal anti-inflammatory drug, it is used for treatment of inflammatory and rheumatic disorders.
Manufacturing Process
Methyl 2-(p-aminophenyl)propionate:
Methyl 2-(p-nitrophenyl)acrylate (52 g) is hydrogenated in ethanol (500 ml) in the presence of 5% palladium-over-charcoal, while maintaining the temperature at +5°C. The theoretical amount of hydrogen is taken up within one hour. After separation of the catalyst and concentration to dryness, the resulting material gives methyl 2-(p-aminophenyl)proprionate which crystallizes: MP: = 40°-43°C.
Methyl 2-(p-methallylaminophenyl)propionate hydrochloride:
A mixture of methyl 2-(p-aminophenyl)propionate (44.75 g), methallyl chloride (34 g) and pyridine (30 ml) in isopropanol (400 ml) is boiled during 30 hours. The solvent is removed in vacuo and the residue is taken up into water and ether. After separation, the organic phase is washed repeatedly with water, after which it is dried and concentrated in vacuo. The resulting oil is fractionally distilled in vacuo (0.1 mm Hg; 5 g of oil essentially consisting of methyl 2-(p-aminophenyl)propionate are collected at 115°-120°C; 30 g of oil consisting of a mixture of mono- (80%) and disubstituted (20%) amines is collected at 128°-130°C. This oil is used to prepare the hydrochloride, which is recrystallized from ethyl acetate, to give white crystals (22.7 g) melting at 115°C. Saponification in the cold methanolic hydroxide gives the desired 2-(4- (methallylamino)phenyl)propionic acid (alminoprofen). MP: 120°C.
Trademarks
MINALFENE
Therapeutic Function
Analgesic, Antiinflammatory

alminoprofen Upstream-Materialien And Downstream Produkte

Alminoprofen Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

39718-89-3, alminoprofen Verwandte Suche:

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