6-beta-acetoxy-3-beta(beta-D-glucopyranosyloxy)-8,14-dihydroxybufa-4,20,22-trienolide Struktur

6 beta-Acetoxy-3 beta(beta-D-glucopyranosyloxy)-8,14-dihydroxy-bufa-4,20,22-trienolid

Bezeichnung:6 beta-Acetoxy-3 beta(beta-D-glucopyranosyloxy)-8,14-dihydroxy-bufa-4,20,22-trienolid

CAS-Nr507-60-8

Englisch Name:6-beta-acetoxy-3-beta(beta-D-glucopyranosyloxy)-8,14-dihydroxybufa-4,20,22-trienolide

CBNumberCB7875355

SummenformelC32H44O12

Molgewicht620.68

MOL-Datei507-60-8.mol

Synonyma

6β-Acetoxy-3beta(β-D-glucopyranosyloxy)-8,14-dihydroxybufa-4,20,22-trienolid

6 beta-Acetoxy-3 beta(beta-D-glucopyranosyloxy)-8,14-dihydroxy-bufa-4,20,22-trienolid

6 beta-Acetoxy-3 beta(beta-D-glucopyranosyloxy)-8,14-dihydroxy-bufa-4,20,22-trienolid physikalisch-chemischer Eigenschaften

Schmelzpunkt	168-170°
alpha	D20 -59 to -60° (methanol)
Siedepunkt	581.69°C (rough estimate)
Dichte	1.1882 (rough estimate)
Brechungsindex	1.6390 (estimate)
pka	12.88±0.70(Predicted)
EPA chemische Informationen	Scilliroside (507-60-8)

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	28
S-Sätze:	36/37-45
RIDADR	2810
HazardClass	6.1(a)
PackingGroup	I
Giftige Stoffe Daten	507-60-8(Hazardous Substances Data)
Toxizität	LD50 in mice (mg/kg): 0.471 s.c.; 0.440 orally (Dybing)

Gefahreninformationscode (GHS)

6-beta-acetoxy-3-beta(beta-D-glucopyranosyloxy)-8,14-dihydroxybufa-4,20,22-trienolide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Red squill (Urginea maritima) is a large onionlike plant that grows in coastal regions along the Mediterranean Sea and in the United States; it contains a variety of cardiac glycosides, including scilliroside. All parts of the plant contain scilliroside but it is most concentrated in the bulb. There is also a white squill whose bulbs are white. Red squill has long been known and used medicinally. The earliest reference to red squill is in the Ebers Papyrus as treatment for dropsy (heart failure). Use as treatment for cough, arthritis, general diuretic, and emetic has also been described. Medicinal use declined during the nineteenth century because foxglove (digitalis) was revealed to be safer and more efficacious in the treatment of heart failure. However, use of red squill as a folk medicinal remedy continues, and deaths and serious illness may occur. Red squill is one of the oldest rodenticides and has been in use since the thirteenth century. However, scilliroside has extremely poor palatability, and many rats learn to avoid the bait. Since 1989, rodenticides containing red squill are not approved for use in the United States.
Verwenden
Rat poisonings containing scilliroside continue to be available and used worldwide. Technical-grade red squill powders can contain up to 28% scilliroside, and baits typically contain 0.01–0.07% of the toxicant.
Toxicity evaluation
Red squill has a multitude of toxic effects. It is directly irritating to the gastric mucosa, contributing to nausea, vomiting, abdominal pain, diarrhea, and anorexia. Rats are not able to vomit, contributing to the perceived selectivity of toxicity in rats. Scilliroside and scillaren A are both cardiac glycosides, and, like digoxin, inhibit Na+/K+ ATPase, block AV conduction, and may cause a slowed or rapid heart rate and abnormal heart rhythms.

6 beta-Acetoxy-3 beta(beta-D-glucopyranosyloxy)-8,14-dihydroxy-bufa-4,20,22-trienolid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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