Naftidrofuryl

Bezeichnung:Naftidrofuryl

CAS-Nr31329-57-4

Englisch Name:NAFRONYL

CBNumberCB7759257

SummenformelC24H33NO3

Molgewicht383.53

MOL-Datei31329-57-4.mol

Synonyma

Naftidrofuryl

Naftidrofuryl physikalisch-chemischer Eigenschaften

Siedepunkt	bp0.5 190°
Dichte	d431 1.0465
Brechungsindex	nD29 1.5513
storage temp.	Refrigerator
Löslichkeit	Chloroform (Slightly), Ethyl Acetate (Slightly)
Aggregatzustand	Oil
pka	9.21±0.25(Predicted)
Farbe	Colourless to Dark Yellow
CAS Datenbank	31329-57-4(CAS DataBase Reference)

Sicherheit

Toxizität

LD50 in mice (mg/kg): 365 orally (Bessin)

Gefahreninformationscode (GHS)

NAFRONYL Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Dusodril,Roland,W. Germany,1968
Verwenden
Nafronyl is a selective inhibitor of serotonin receptors. Nafronyl is a vasodilator used in the treatment of intermittent claudication.
Verwenden
Vasodilator.
Definition
ChEBI: 2-(1-naphthalenylmethyl)-3-(2-oxolanyl)propanoic acid 2-(diethylamino)ethyl ester is a member of naphthalenes.
Manufacturing Process
30 grams (0.106 mol) of β-(1-naphthyl)-β'-tetrahydrofuryl isobutyric acid are heated under reflux for 8 1/2 hours in 230 cc of isopropanol with 14 grams (0.103 mol) of β-chloroethyl-N-diethylamine. After evaporation of the isopropanol in vacuo, the syrupy residue is treated with a solution of K2CO3. Extraction with ether is carried out after drying over Na2SO4.
Distillation of the extract yields 28.5 grams of a very viscous yellow liquid with a BP0.95-1.09millibar = 198° to 202°C. The yield is 70.5% (theoretical quantity = 40.5 grams).1.3 grams (0.0103 mol) of dihydrated oxalic acid are dissolved while being made tepid in 8 cc of acetone. The cooled solution has added thereto 4 grams (0.0104 mol) of N-diethylaminoethyl-β-(1-naphthyl)-β'- tetrahydrofuryl isobutyrate, obtained according to the process described above and dissolved in 10 cc of acetone. The solution is brought to boiling point for 15 minutes. After cooling to ambient temperature, it is placed in a refrigerator. Crystallization occurs after 2 hours, the crystals which have formed are separated by centrifuging, and after washing in hexane and drying in vacuo 3.5 grams of white crystals are obtained. After being recrystallized three times, in alcohol and then in a mixture of alcohol and ethyl acetate, the product is analytically pure and has a MP = 110° to 111°C (heating stage).
Trademarks
Praxilene (Lipha, S.A., France).
Therapeutic Function
Vasodilator
Weltgesundheitsorganisation (WHO)
Naftidrofuryl is a vasoactive spasmolytic used to treat peripheral vascular disease. It also improves the oxygen utilization in tissues.

NAFRONYL Upstream-Materialien And Downstream Produkte

Naftidrofuryl Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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