Monensin, Mononatriumsalz

Bezeichnung:Monensin, Mononatriumsalz

CAS-Nr22373-78-0

Englisch Name:Monensin sodium salt

CBNumberCB7748020

SummenformelC36H63NaO12

Molgewicht710.87

MOL-Datei22373-78-0.mol

Synonyma

Monensin, Mononatriumsalz

Monensin, Mononatriumsalz physikalisch-chemischer Eigenschaften

Schmelzpunkt	267-269 C
alpha	57.3 º (c=4.0, in MeOH)
storage temp.	2-8°C
Löslichkeit	Soluble in methanol at 50mg/ml
Aggregatzustand	Off-white to beige solid
Farbe	White
BRN	4122200
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey	XOIQMTLWECTKJL-BEMBKCOJSA-M
LogP	3.716 (est)
EPA chemische Informationen	Monensin, monosodium salt (22373-78-0)

Sicherheit

Kennzeichnung gefährlicher	T,T+
R-Sätze:	25-26/27/28
S-Sätze:	36/37/39-45-22
RIDADR	UN 3462 6.1/PG 2
WGK Germany	3
RTECS-Nr.	JH2830000
HazardClass	6.1(a)
PackingGroup	II
HS Code	29419090

Gefahreninformationscode (GHS)

Monensin sodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.
Beschreibung
Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.
Chemische Eigenschaften
LIGHT CREAM AMORPHOUS POWDER
Verwenden
Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.
Verwenden
antibacterial
Verwenden
antifungal
Verwenden
Poliether antibiotic. Coccidiostat.
Allgemeine Beschreibung
Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis?in poultry production.
Biochem/physiol Actions
Na+ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.
Lager
-20°C
läuterung methode
Crystallise it from EtOH/H2O [Cox et al. J Am Chem Soc 107 4297 1985].
Einzelnachweise
Aowicki and Huczynski (2013), Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements; Res. Int. 2013 742149 Kallen et al. (1993), Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells; Biophys. Acta 1166 305 Boss et al. (1984), Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient; J. Cell. Biol. 34 1 Mollenhauer et al. (1990), Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity; Biophys. Acta 1031 225 Hafner et al. (2021), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells; Pharmacol. 12 611657 Oh-Hashi et al. (2021), Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells; J. Mol. Sci. 22 2767

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