3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8,8-dimethyl-8-azoniabicyclo-(3.2.1)octan-nitrat, endo-(+-)-

Bezeichnung:3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8,8-dimethyl-8-azoniabicyclo-(3.2.1)octan-nitrat, endo-(+-)-

CAS-Nr52-88-0

Englisch Name:ATROPINE METHYL NITRATE

CBNumberCB7747265

SummenformelC18H26N2O6

Molgewicht366.41

MOL-Datei52-88-0.mol

Synonyma

Atropinmethonitrat

3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8,8-dimethyl-8-azoniabicyclo-(3.2.1)octan-nitrat, endo-(+-)-

3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8,8-dimethyl-8-azoniabicyclo-(3.2.1)octan-nitrat, endo-(+-)- physikalisch-chemischer Eigenschaften

Schmelzpunkt	163°C
storage temp.	-20°C
Löslichkeit	H₂O: 50 mg/mL
Aggregatzustand	powder
Farbe	white
Merck	875
CAS Datenbank	52-88-0(CAS DataBase Reference)
EPA chemische Informationen	Methylatropine nitrate (52-88-0)

Sicherheit

Kennzeichnung gefährlicher	Xn,T+
R-Sätze:	22-26/28
S-Sätze:	22-36-45-25
RIDADR	1544
WGK Germany	3
RTECS-Nr.	CK2800000
Toxizität	LD50 oral in rat: 1902mg/kg

Gefahreninformationscode (GHS)

ATROPINE METHYL NITRATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
mp 162-164 C
Originator
Methylatropine,Paganfarma
Verwenden
Atropine methyl nitrate has been used to suppress mucus production and respiratory secretions in rats. It has also been used to study its effects on xanomeline-induced suppression of serum tumor necrosis factor.
Verwenden
cephalosporin antimicrobial
Verwenden
antibacterial
Manufacturing Process
There are 2 methods of synthesis of methyl atropine nitrate:
1) To a solution of 28.9 g atropine of in 100 g of methanol was added at 110°C for 2 hours 7.7 g methyl nitrate. Methanol was evaporated and methyl atropine nitrate was crystallysed, M.P. 163°C.
2) To a solution of 70.4 g methyl atropine sulfate (prepared from methyl atropine chloride and silver nitrate) in water was added aqueous solution of 26.1 g barium nitrate. Barium sulfate was deleted by filtration. Filtrate was concentrated and the methyl atropine nitrate was obtained.
Trademarks
Ekomine (Hoechst-Roussel); Eumydrin (Sterling Winthrop).
Therapeutic Function
Anticholinergic, Mydriatic, Spasmolytic
Biochem/physiol Actions
Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (bladder, respiratory, to block parasympathetic signaling to the heart, etc.) and to separate central from peripheral effects or protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.
Sicherheitsprofil
Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ATROPINE and NITRATES.

ATROPINE METHYL NITRATE Upstream-Materialien And Downstream Produkte

3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8,8-dimethyl-8-azoniabicyclo-(3.2.1)octan-nitrat, endo-(+-)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

52-88-0, ATROPINE METHYL NITRATE Verwandte Suche:

Send Inquriy