2-Chlornicotinsaeure

Bezeichnung:2-Chlornicotinsaeure

CAS-Nr2942-59-8

Englisch Name:2-Chloronicotinic acid

CBNumberCB7714896

SummenformelC6H4ClNO2

Molgewicht157.55

MOL-Datei2942-59-8.mol

Synonyma

2-Chlornicotinsaeure

2-Chlornicotinsaeure physikalisch-chemischer Eigenschaften

Schmelzpunkt	176-178 °C (dec.)(lit.)
Siedepunkt	316.8±22.0 °C(Predicted)
Dichte	1.470±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO, Ethyl Acetate (Slightly)
pka	2.07±0.25(Predicted)
Aggregatzustand	Powder
Farbe	White to cream
Geruch (Odor)	Pungent odor
BRN	119023
InChI	InChI=1S/C6H4ClNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3H,(H,9,10)
InChIKey	IBRSSZOHCGUTHI-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=CC=C1C(O)=O
LogP	0.988
CAS Datenbank	2942-59-8(CAS DataBase Reference)
EPA chemische Informationen	2-Chloronicotinic acid (2942-59-8)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	22-24/25-37/39-26-36
WGK Germany	3
TSCA	T
HazardClass	IRRITANT
HS Code	29333999

Gefahreninformationscode (GHS)

2-Chloronicotinic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white to cream powder. MP>175°C (decomposition), insoluble in water, soluble in organic solvents such as benzene and toluene.
Verwenden
2-Chloronicotinic Acid is used in the preparation of 4-thiazolidinone derivatives and Schiff bases displaying antimicrobial activity.
Application
2-Chloronicotinic acid is used in the synthesis of the anti-inflammatory and analgesic pralofen. It is an intermediate of the herbicides nicosulfuron and diflufenican. It is also used as pharmaceutical intermediates for the manufacture of mefenamic acid, niflumic acid, etc.
synthetische
Chloronicotinic acid was synthesized from nicotinic acid by oxidation by H2O2 and then chlorinationby POCl3 and PCl5 in a yield of 87.5%.
Synthesis of 2-chloronicotinic acid: Pour chlorine gas into the mixed solution of phosphorus oxychloride and phosphorus trichloride, control the temperature at about 60°C, until the remaining chlorine gas escapes, cool and add nicotinic acid N-oxide in batches, and heat the mixed solution. The reaction was carried out at 100-105°C for 1-1.5 h, and the reaction mixture was stirred for 30 min after the reaction mixture was transparent, and phosphorus oxychloride was removed under reduced pressure. The obtained residue was cooled to room temperature, and water was added to obtain the finished product of 2-chloronicotinic acid.
Definition
ChEBI: 2-Chloronicotinic acid is an aromatic carboxylic acid and a member of pyridines.

2-Chloronicotinic acid Upstream-Materialien And Downstream Produkte

2-Chlornicotinsaeure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2942-59-8, 2-Chloronicotinic acid Verwandte Suche:

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