(±)-Cloprostenol sodium salt

Bezeichnung:(±)-Cloprostenol sodium salt

CAS-Nr55028-72-3

Englisch Name:(±)-Cloprostenol sodium salt

CBNumberCB7699245

SummenformelC22H30ClNaO6

Molgewicht448.92

MOL-Datei55028-72-3.mol

(±)-Cloprostenol sodium salt physikalisch-chemischer Eigenschaften

Schmelzpunkt	68-70 °C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	H₂O: >10 mg/mL
Aggregatzustand	solid
Farbe	light brown
Wasserlöslichkeit	H2O: >10mg/mL
InChIKey	IFEJLMHZNQJGQU-KXXGZHCCSA-M
CAS Datenbank	55028-72-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	60-22-36/37/38
S-Sätze:	53-26-36/37/39-45
WGK Germany	3
HS Code	2937500000

Gefahreninformationscode (GHS)

(±)-Cloprostenol sodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
±)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α.
Verwenden
(±)-Cloprostenol sodium salt is a prostaglandin that dissolves the corpus luteum of cattle and is used as a veterinary drug.
Trademarks
Estrumate(Bayer Animal Health).
Allgemeine Beschreibung
Cloprostenol sodium (Estrumate)is available as the sodium salt from Bayer AgriculturalDivision or Bayvet Division of Miles Laboratory as an aqueoussolution containing 250 mg/mL.
Biologische Aktivität
Water-soluble prostaglandin F 2 α (PGF 2 α ) analog; acts as a potent FP receptor agonist (EC 50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo .
Nebenwirkungen
A low incidence of clostridial and other infections at the injection site has been reported following prostaglandin administration. Treated animals should be closely observed post injection and appropriate antibiotic therapy initiated at the first sign(s) of infection.
Very rarely, anaphylactic reactions have occurred after administration of the product. Overdose: At 50 and 100 times the recommended dose of cloprostenol mild side effects may be detected. These include increased uneasiness, mild transient diarrhea, slight frothing, and milk letdown.
Veterinary Drugs and Treatments
Cloprostenol is approved for use in beef or dairy cattle to induce luteolysis. It is recommended by the manufacturer for unobserved or undetected estrus in cows cycling normally, pyometra or chronic endometritis, expulsion of mummified fetus, luteal cysts, induced abortions after mismating, and to schedule estrus and ovulation for controlled breeding.
Cloprostenol has been used in dogs for pregnancy termination and treatment of open pyometra. The use of cloprostenol for pyometra is controversial as some believe dinoprost (PGF2alpha) is more effective and has fewer adverse effects than cloprostenol.
Solubility in water
Soluble in H₂O.

(±)-Cloprostenol sodium salt Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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