7-Nitro-1H-indol-2-carbonsure

Bezeichnung:7-Nitro-1H-indol-2-carbonsure

CAS-Nr6960-45-8

Englisch Name:7-Nitroindole-2-carboxylic acid

CBNumberCB7682546

SummenformelC9H6N2O4

Molgewicht206.15

MOL-Datei6960-45-8.mol

Synonyma

7-Nitro-1H-indol-2-carbonsure

7-Nitro-1H-indol-2-carbonsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	260-261 °C
Siedepunkt	344.99°C (rough estimate)
Dichte	1.4588 (rough estimate)
Brechungsindex	1.5570 (estimate)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
Löslichkeit	DMSO: >20mg/mL
Aggregatzustand	Tan solid
pka	4.03±0.30(Predicted)
Wasserlöslichkeit	Insoluble
CAS Datenbank	6960-45-8(CAS DataBase Reference)
EPA chemische Informationen	1H-Indole-2-carboxylic acid, 7-nitro- (6960-45-8)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	36/37/38-21/22-43-36
S-Sätze:	36/37/39-26-22-36/37
WGK Germany	3
TSCA	Yes
HazardClass	IRRITANT
HS Code	2933998090

Gefahreninformationscode (GHS)

7-Nitroindole-2-carboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S22:Staub nicht einatmen.
Chemische Eigenschaften
brown powder
Verwenden
7-Nitro-1H-indole-2-carboxylic Acid is a potent and selective APE1 inhibitor, which at low micromolar concentrations inhibits the AP endonuclease, 3''-phosphodiesterase and 3''-phosphatase activities of APE1 .
Biologische Aktivität
crt0044876 is a potent and selective inhibitor of ape1 with ic50 value of 3.06 μm [1].apurinic/apyrimidinic endonuclease-1 (ape1) is a member of the highly conserved exonucleaseiii family of ap endonucleases and plays an important role in dna repair. ape1 exhibits 3’-phosphodiesterase activity and weak 3’-phosphatase activity, 3’-5’-exonuclease activity and rnaseh activity [1].crt0044876 is a potent and selective ape1 inhibitor. in hela whole cell extract, crt0044876 inhibited apurinic/apyrimidinic (ap) site cleavage catalyzed by ape1. crt0044876 inhibited both the ap endonuclease and exonuclease activities of exonuclease iii, the bacterial homologue of ape1. crt0044876 inhibited the 3’-phosphoglycolate diesterase activity of ape1 with ic50 value of 5 μm and also inhibited 3’-phosphatase activity through binding to dna repair active site of ape1. in ht1080 fibrosarcoma cells, crt0044876 significantly increased ap site accumulation and was non-toxic at concentrations up to 400 μm. also, crt0044876 potentiated the cytotoxicity induced by alkylating agent mms, temozolomide, hydrogen peroxide and hmdurd through specific inhibition of the base excision repair (ber) pathway [1].
Einzelnachweise
[1]. madhusudan s, smart f, shrimpton p, et al. isolation of a small molecule inhibitor of dna base excision repair. nucleic acids res, 2005, 33(15): 4711-4724.

7-Nitroindole-2-carboxylic acid Upstream-Materialien And Downstream Produkte

7-Nitro-1H-indol-2-carbonsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6960-45-8, 7-Nitroindole-2-carboxylic acid Verwandte Suche:

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