CANNABIDIOL

Bezeichnung:CANNABIDIOL

CAS-Nr13956-29-1

Englisch Name:CANNABIDIOL

CBNumberCB7673434

SummenformelC21H30O2

Molgewicht314.46

MOL-Datei13956-29-1.mol

CANNABIDIOL physikalisch-chemischer Eigenschaften

Schmelzpunkt	62-63°C
alpha	D27 -125° (0.066 g in 5 ml 95% ethanol); D18 -129° (c = 0.45 in ethanol)
Siedepunkt	bp2 187-190° (bath temp 220°); bp0.001 130°
Dichte	d440 1.040
Brechungsindex	nD20 1.5404
Flammpunkt	11 °C
storage temp.	2-8°C
Löslichkeit	Soluble to 75 mM in ethanol and to 75 mM in DMSO
Aggregatzustand	powder
Farbe	White
InChIKey	QHMBSVQNZZTUGM-ZWKOTPCHSA-N
LogP	6.600 (est)
EPA chemische Informationen	1,3-Benzenediol, 2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl- (13956-29-1)

Sicherheit

Kennzeichnung gefährlicher	F,T
R-Sätze:	11-23/24/25-39/23/24/25
S-Sätze:	36/37-45-16-7
RIDADR	UN 1230 3/PG 2
WGK Germany	1
RTECS-Nr.	VH1600000

Gefahreninformationscode (GHS)

CANNABIDIOL Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S16:Von Zündquellen fernhalten - Nicht rauchen.
S7:Behälter dicht geschlossen halten.
Beschreibung
Cannabidiol (CRM) (Item No. ISO60156) is a certified reference material categorized as a phytocannabinoid. Unlike Δ⁹-THC (Item Nos. ISO60157 | 12068), cannabidiol is non-psychoactive. This product is intended for research and forensic applications.
Chemische Eigenschaften
Off-White Solid
Verwenden
Major non-psychoactive constituent of Cannabis. Exhibits multiple bioactivities including anticonvulsant, anxiolytic and anti-inflammatory effects. The (+)-isomers were more active than the (-)-isomers.
Definition
ChEBI: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Biologische Aktivität
Non-psychotropic constituent of cannabis that is anticonvulsive, antihyperalgesic and neuroprotective in vivo . GPR55 and weak CB 1 antagonist (IC 50 values are 0.445 and 3.35 μ M), CB 2 receptor inverse agonist and inhibitor of anandamide uptake (IC 50 = 27.5 μ M). Also a weak agonist at VR1 vanilloid receptors (EC 50 = 3.5 μ M).
Pharmakologie
Cannabidiol, a constituent of the cannabis plant, has been receiving considerable attention of late for its potential therapeutic utility, including potential anxiolytic, anticonvulsant,anti-inflammatory, and neuroprotective effects. Cannabidiol has a complex pharmacology. In contrast to THC, cannabidiol has minimal affinity for CB1 and CB2 receptors and produces no intoxication. The effects of cannabidiol in combination with THC have been mixed, with some data suggesting it may reduce THC’s mood-altering and cognitive effects, while others show no effect. If oral cannabidiol reduces cannabis intoxication, it could be a potential medication to treat CUD. However, Haney et al. tested a range of cannabidiol doses (200–800 mg) in combination with active and placebo cannabis and found no cannabidiol effect on the subjective, reinforcing, or cardiovascular effects of smoked cannabis, providing little support for cannabidiol’s utility as a medication to reduce cannabis’ positive reinforcing and subjective effects.
target
JNK | MAPK | P450 (e.g. CYP17) | TNF-α | COX | NF-kB | Caspase | 5-HT Receptor
Lager
-20°C

CANNABIDIOL Upstream-Materialien And Downstream Produkte

13956-29-1, CANNABIDIOL Verwandte Suche:

Send Inquriy