XCT 790 Struktur

XCT 790

Bezeichnung:XCT 790

CAS-Nr725247-18-7

Englisch Name:XCT 790

CBNumberCB7505302

SummenformelC23H13F9N4O3S

Molgewicht596.42

MOL-Datei725247-18-7.mol

XCT 790 physikalisch-chemischer Eigenschaften

storage temp.	2-8°C
Löslichkeit	DMSO: ≥10mg/mL
Aggregatzustand	solid
Farbe	yellow

Sicherheit

WGK Germany

Gefahreninformationscode (GHS)

XCT 790 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
XCT790 is an inverse agonist of estrogen-related receptor α (ERRα; IC₅₀ = ~300-500 nM). It demonstrates 90-100% inhibition of ERRα constitutive activity and has no significant activity at related nuclear receptors at 10 μM. XCT790 associates with the ligand-binding domain of ERRα and blocks ERRα/PGC-1α-dependent signaling, suppressing the expression of monoamine oxidases A and B. XCT790 induces proteasomal degradation of ERRα and potentiates the degradation of the estrogen receptor ERα by fulvestrant .
Verwenden
XCT790 is a potent inverse agonist of ERRα.
Definition
ChEBI: XCT 790 is a member of cinnamamides.
Biochem/physiol Actions
XCT 790 is a 5′adenosine monophosphate-activated protein kinase (AMPK) activator. It also acts as a proton ionophore and an uncoupler of oxidative phosphorylation in mitochondria. XCT790 impairs vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang-2) expression and exhibits suppression of endometrial tumor via estrogen-related receptor (ERRα) inhibition. XCT790 mediates cell cycle arrest and favors apoptosis in triple-negative breast cancer (TNBC).
Lager
Store at +4°C
Einzelnachweise
[1] lu x, peng l, lv m, ding k. recent advance in the design of small molecular modulators of estrogen-related receptors. curr pharm des. 2012;18(23):3421-31.
[2] wu f, wang j, wang y, kwok tt, kong sk, wong c. estrogen-related receptor alpha (erralpha) inverse agonist xct-790 induces cell death in chemotherapeutic resistant cancer cells. chem biol interact. 2009 oct 7;181(2):236-42.

XCT 790 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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