4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on

Bezeichnung:4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on

CAS-Nr83-07-8

Englisch Name:4-Aminoantipyrine

CBNumberCB7485059

SummenformelC11H13N3O

Molgewicht203.24

MOL-Datei83-07-8.mol

Synonyma

4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on

4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	105-110 °C(lit.)
Siedepunkt	340 C
Dichte	0.8
Brechungsindex	1.4930 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	H₂O: 0.1 g/mL, clear
pka	pK1: 4.94(+1) (25°C)
Aggregatzustand	Powder or Crystals
Farbe	Yellow to yellow-brown
PH	7.1 (100g/l, H2O, 20℃)(slurry)
Geruch (Odor)	Odorless
Wasserlöslichkeit	ca. 500 g/L (20 ºC)
Merck	14,591
BRN	181635
Stabilität	Stable. May be light sensitive.
LogP	-0.257 (est)
CAS Datenbank	83-07-8(CAS DataBase Reference)
NIST chemische Informationen	Aminoantipyrene(83-07-8)
EPA chemische Informationen	4-Aminoantipyrene (83-07-8)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38-20/21/22
S-Sätze:	26-36-36/37/39
WGK Germany	3
RTECS-Nr.	CD2480000
F	8-9-23
Hazard Note	Harmful
TSCA	Yes
HS Code	29331190
Toxizität	LD50 orally in Rabbit: 1700 mg/kg

Gefahreninformationscode (GHS)

4-Aminoantipyrine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Amber crystalline powder
Application
4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample.
Verwenden
4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.
4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.
synthetische
synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine.
Definition
ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine.
Allgemeine Beschreibung
4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals.
läuterung methode
It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]

4-Aminoantipyrine Upstream-Materialien And Downstream Produkte

4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

83-07-8, 4-Aminoantipyrine Verwandte Suche:

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