Diflucortolone valerate Struktur

6α,9-Difluor-11β,21-dihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-valerat

Bezeichnung:6α,9-Difluor-11β,21-dihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-valerat

CAS-Nr59198-70-8

Englisch Name:Diflucortolone valerate

CBNumberCB7420627

SummenformelC27H36F2O5

Molgewicht478.57

MOL-Datei59198-70-8.mol

Synonyma

6α,9-Difluor-11β,21-dihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-valerat

6α,9-Difluor-11β,21-dihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-valerat physikalisch-chemischer Eigenschaften

Schmelzpunkt	220°C
alpha	D22 +100.8° (dioxane)
Siedepunkt	578.5±50.0 °C(Predicted)
Dichte	1.1227 (estimate)
storage temp.	-20°C Freezer, Under inert atmosphere
Löslichkeit	Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	12.89±0.70(Predicted)
Farbe	White to Off-White

Sicherheit

Toxizität

Approx LD50 in mice, rats: >4, 3.1 g/kg orally; 180, 13 mg/kg s.c.; 450, 98 mg/kg i.p. (Gunzel).

Gefahreninformationscode (GHS)

Diflucortolone valerate Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Nerisone,Schering,UK,1976
Verwenden
The 9α-fluoro derivative of Fluocortolone (F500500). Anti-inflammmatory.
Definition
ChEBI: Diflucortolone valerate is a corticosteroid hormone.
Manufacturing Process
16α-Methyl-6α,9α-difluoro-δ4-pregnene-11α,21-diol-3,20-dione-21-acetate (MP = 229°/232°-234°C (with decomposition) is dehydrogenated in 1.2- position by means of Bacillus lentus, Mutant MB 284, whereby the 21-acetate group is simultaneously saponified. (It is possible under the same conditions to start with the free 21-hydroxyl compound.)
For this purpose a fermenter made of stainless steel having a 50 liter capacity is charged with 30 liters of a nutrient solution of 0.1% yeast extract, 0.5% cornsteep and 0.2% glucose, heated for one-half hour at 120°C for sterilization purposes, and after cooling, inoculated with a bacterial suspension of Bacillus lentus MB 284.
After 24 hours of growth at 28°C under stirring (220 revolutions per minute) and aeration (1.65 m3/hr), 1.8 liters of the obtained culture is removed under sterile conditions and transferred with 28 liters of the same sterilized nutrient medium into a fermenter of the same size.
Simultaneously, 6 g of 16α-methyl-6α,9α-difluoro-δ4-pregnene-11β,21-diol3,20-dione-21-acetate in 200 cc of dimethylformamide are added and the fermentation is continued for 50 hours under the same conditions.
The course of the fermentation is tested by removal of samples which are extracted with methyl isobutyl ketone. The extracts are analyzed by thin layer chromatography using a system of benzene/ethyl acetate (4:1).
After further working up there is obtained an oily crystalline residue which is subjected to chromatography on silica gel. The 16α-methyl-6α,9α-difluoroδ1,4-pregnadien-11β,21-diol-3,20-dione is eluated with ethyl acetatechloroform (1:2), it is recrystallized from ethyl acetate/ether and then formed to melt at 240°/242°-244°C. The yield is 60% of the theoretical. The product is reacted with valeric acid chloride to give the valerate ester.
Therapeutic Function
Antiinflammatory

Diflucortolone valerate Upstream-Materialien And Downstream Produkte

6α,9-Difluor-11β,21-dihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-valerat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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