SCOULERIN

SCOULERIN Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  This form of the alkaloid is more widespread than the d-form, occurring in Corydalis caseana, C. micrantha, C. montana, C. scouleri, C. sibirica and Papaver somniferum. It has [α]²⁶_D - 318° (c 0.41, MeOH) or - 289° (c 0.62, MeOH). It forms pale grey needles when crystallized from MeOH. The hydrochloride has m.p. 268-9°C; the picrate, m.p. 206°C (dec.) and the diethyl ether, m.p. 155°C. The oxidation products are the same as for the preceding base.

• Chemische Eigenschaften

  Off-White to Pale Pink Solid

• Verwenden

  (S)-Scoulerine is an alkaloid found in the opium poppy. (S)-Scoulerine acts as an antagonist at the α2-adrenoceptor, α1D-adrenoceptor and 5-HT receptor.

• Verwenden

  The S-(+)-enantiomer of Scoulerine, an alkaloid found in the opium poppy.

• Definition

  ChEBI: A berberine alkaloid isolated from Corydalis saxicola.

• Einzelnachweise

  Manske., Can. J. Res., 14B, 347, 354 (1936)
  Manske., ibid, 17B, 57 (1939)
  Manske., ibid, 18B, 414 (1940)
  Manske., ibid, 20B, 49 (1942)
  Brochmann-Hanssen, Nielsen., Tetrahedron Lett., 2261 (1966)
  Synthesis:
  Kametani., Japanese Patent, 70, 37,976, 10 December 1970

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