Bromnitromethan

Bezeichnung:Bromnitromethan

CAS-Nr563-70-2

Englisch Name:Bromonitromethane

CBNumberCB7381067

SummenformelCH2BrNO2

Molgewicht139.94

MOL-Datei563-70-2.mol

Synonyma

Bromnitromethan

Bromnitromethan physikalisch-chemischer Eigenschaften

Schmelzpunkt	-28 °C
Siedepunkt	146-148 °C/750 mmHg (lit.)
Dichte	2.007 g/mL at 25 °C (lit.)
Brechungsindex	1.485-1.495
Flammpunkt	4°C
Löslichkeit	Chloroform (Soluble), DMSO (Sparingly), Ethyl Acetate (Slightly), Methanol (Slig
pka	7.22±0.29(Predicted)
Aggregatzustand	Liquid
Farbe	Clear yellow
Stabilität	Light Sensitive, Volatile
CAS Datenbank	563-70-2(CAS DataBase Reference)
EPA chemische Informationen	Methane, bromonitro- (563-70-2)

Sicherheit

Kennzeichnung gefährlicher	Xn-O,Xi,O
R-Sätze:	8-36/37/38-20/21/22
S-Sätze:	36/37/39-26-17-36
RIDADR	3098
WGK Germany	3
RTECS-Nr.	PA5360000
HazardClass	5.1
PackingGroup	III
HS Code	29049095

Gefahreninformationscode (GHS)

Bromonitromethane Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R8:Feuergefahr bei Berührung mit brennbaren Stoffen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S17:Von brennbaren Stoffen fernhalten.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Bromonitromethane is a clear yellow liquid, It is a strong oxidizing agent with properties similar to nitromethane.
Bromonitromethane has been used:
in production of various protected α-bromo nitroalkane donors (including Fmoc) for use in Umpolung amide synthesis.
in preparation of (Z)-1-bromo-1-nitroalkenes via sodium iodide-catalyzed Henry reaction.
in diastereo- and enantioselective cyclopropanation of β,γ-unsaturated a-ketoesters via domino Michael-addition/intramolecular-alkylation strategy.
Verwenden
Bromonitromethane has received considerable attention as a one-carbon synthon for the synthesis of a variety of important organic intermediates.
Bromonitromethane is a key starting material for the preparation of the broad-spectrum antibiotic trovafloxacin, which contains the interesting 3-azabicyclo[ 3.1.0]hexane ring system.
it was used in the synthesis of 2-nitrobenzofuran and 2-nitro-2,3-dihydrobenzofuran-3-ols, nitrobenzothio-phenes, and nitrothiazoles, polyfunctionalized nitrocyclopropanes. It has also been utilized in the synthesis of 1-bromo-1-nitroalkan-2-ols and aryl nitromethanes. In addition, it could be used as a bromine donor.
Verwenden
Bromonitromethane has been used:
- in production of various protected α-bromo nitroalkane donors (including Fmoc) for use in Umpolung amide synthesis
- in preparation of (Z)-1-bromo-1-nitroalkenes via sodium iodide-catalyzed Henry reaction
- in diastereo- and enantioselective cyclopropanation of β,γ-unsaturated a-ketoesters via domino Michael-addition/intramolecular-alkylation strategy
synthetische
Bromonitromethane is commercially available and can also be easily prepared according to the procedures reported by Fishwick et al. A typical procedure is as following: freshly distilled nitromethane was stirred at 0℃ and bromine was dropped in 5 seconds. The resulted bromonitromethane could be used without further purification.

Bromonitromethane Upstream-Materialien And Downstream Produkte

Bromnitromethan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

563-70-2, Bromonitromethane Verwandte Suche:

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