DIPHENYLENEIODONIUM CHLORIDE

Bezeichnung:DIPHENYLENEIODONIUM CHLORIDE

CAS-Nr4673-26-1

Englisch Name:DIPHENYLENEIODONIUM CHLORIDE

CBNumberCB7355273

SummenformelC12H8ClI

Molgewicht314.55

MOL-Datei4673-26-1.mol

DIPHENYLENEIODONIUM CHLORIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	312-322 °C
storage temp.	room temp
Löslichkeit	Soluble in DMSO (up to 5 mg/ml with warming)
Aggregatzustand	Powder
Farbe	Off-white
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36
S-Sätze:	26
WGK Germany	3
HS Code	29310099

Gefahreninformationscode (GHS)

DIPHENYLENEIODONIUM CHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Diphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX; EC₅₀ = 0.1 μM in HeLa cells). It also inhibits nitric oxide synthase (NOS; IC₅₀ = 0.05 μM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 μM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical vein endothelial cells (HUVECs). It inhibits NETosis induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils when used at a concentration of 10 μM. DPI (2 mg/kg) reduces tumor growth in HT-29 and LS 174T colon cancer mouse xenograft models.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase. Solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90
Verwenden
Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase.Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90
Definition
ChEBI: An organic chloride salt having dibenziodolium as the counterion.
Biochem/physiol Actions
A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.
Lager
Desiccate at -20°C
Einzelnachweise
1) Stuehr?et al.?(1991),?Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs; FASEB J.,?5?98 2) Yea?et al.?(1990),?Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase; Biochem. J.,?265?95 3) Ye?et al.?(2014),?Identification of a novel small-molecule agonist for human G protein-coupled receptor 3; J. Pharmacol. Exp. Ther.,?349?4371 4) Mendes?et al.?(2001),?Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species; Mediators Inflamm.,?10?209 5) Kono?et al.?(2001),?Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat;?Am. J. Physiol. Gastrointest. Liver Physiol.,?280?G1005

DIPHENYLENEIODONIUM CHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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