IMETIT DIHYDROBROMIDE Struktur

IMETIT DIHYDROBROMIDE

Bezeichnung:IMETIT DIHYDROBROMIDE

CAS-Nr32385-58-3

Englisch Name:IMETIT DIHYDROBROMIDE

CBNumberCB7305203

SummenformelC6H12Br2N4S

Molgewicht332.06

MOL-Datei32385-58-3.mol

IMETIT DIHYDROBROMIDE physikalisch-chemischer Eigenschaften

storage temp.	Store at RT
Löslichkeit	H₂O: soluble
Aggregatzustand	solid
Farbe	off-white
Wasserlöslichkeit	Freely soluble in water, practically insoluble in acetone /n

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

IMETIT DIHYDROBROMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Imetit is a histamine H₃ and H₄ receptor agonist (K_is = 0.3 and 2.7 nM, respectively, in radioligand binding assays). It is selective for histamine H₃ and H₄ receptors over H₁ and H₂ receptors at concentrations up to 100 μM, as well as the serotonin (5-HT) receptor subtype 5-HT₃ (K_i = 240 nM)., Imetit reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC₅₀ = 2.8 nM). It increases scratching in mice (ED₅₀ = 0.9 μmol), an effect that is reduced by the H₃ receptor antagonist thioperamide .
Verwenden
Imetit dihydrobromide is a high affinity agonist at the histamine H3- and H4-receptors.
Definition
ChEBI: A hydrobromide salt obtained by reaction of imetit with two equivalents of hydrobromic acid. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces sh pe change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.
Biologische Aktivität
An extremely potent, high affinity agonist at H 3 and H 4 receptors (K i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC 50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H 3 Receptor Tocriset™ .
Biochem/physiol Actions
Potent and selective H3 histamine receptor agonist.
Lager
Store at RT

IMETIT DIHYDROBROMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

32385-58-3, IMETIT DIHYDROBROMIDE Verwandte Suche:

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