Dorzolamide Hydrochloride

Bezeichnung:Dorzolamide Hydrochloride

CAS-Nr130693-82-2

Englisch Name:Dorzolamide Hydrochloride

CBNumberCB7296763

SummenformelC10H16N2O4S3.ClH

Molgewicht360.9

MOL-Datei130693-82-2.mol

Dorzolamide Hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	265-2670C
alpha	D24 -8.34° (c = 1 in methanol)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol.
Aggregatzustand	Solid
Farbe	White to Off-White
maximale Wellenlänge (λmax)	254nm(CHCl3:MeOH= aq.)(lit.)
Merck	14,3426
BRN	5896026
CAS Datenbank	130693-82-2(CAS DataBase Reference)

Sicherheit

WGK Germany	3
RTECS-Nr.	XJ9095163
HS Code	2935904000

Gefahreninformationscode (GHS)

Dorzolamide Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Dorzolamide hydrochloride was introduced in the U.S.A. as eye drops for the treatment of open-angle glaucoma and ocular hypertension. Dorzolamide is a potent carbonic anhydrase inhibitor that, on topical administration, lowers intraocular pressure (IOP). In a clinical study in patients with bilateral primary open-angle glaucoma or ocular hypertension, dorzolamide (0.7-2%) was found to significantly lower IOP throughout the day. Dorzolamide has been shown to be effective as a single therapy or in combination with β-blockers.
Beschreibung
Dorzolamide (hydrochloride) (Item No. 26303) is an analytical reference standard categorized as a carbonic anhydrase inhibitor diuretic. Diuretics have been used in sports doping to reduce weight or anabolic androgenic steroid-induced water retention, or as masking agents. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .
Chemische Eigenschaften
White Powder
Originator
Merck (U.S.A.)
Verwenden
An inhibitor of carbonic anhydrase.
Verwenden
Dorzolamide HCl Ophthalmic Solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Verwenden
Antiglaucoma drug;Carbonic anhydrase inhibitor
Verwenden
analgesic
Verwenden
Carbonic anhydrase inhibitor. Antiglaucoma agent.
Definition
ChEBI: The hydrochloride salt of dorzolamide. It is used in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.
Manufacturing Process
Manufacturing process for Dorzolamide hydrochloride includes these steps as follows: Step A: Sulfuric Acid Ritter Procedure;Step B: Sulfonylation Procedure Step C: Chlorosulfonylation Procedure;Step D: Amidation Procedure;Step E: Reduction via Borane Generated in situ Procedure;Step F: Maleate Salt Formation Procedure;Step G: Crude Hydrochloride Salt Formation;Step H: Recrystallization Procedure.
Trademarks
Trusopt (Merck).
Therapeutic Function
Antiglaucoma
Veterinary Drugs and Treatments
Dorzolamide is often used in the contralateral eye of a dog with primary glaucoma to prevent development of bilateral disease. It is also an excellent agent to consider for most secondary glaucomas in dogs and cats because it has no effect on pupil size. Like the related oral carbonic anhydrase inhibitors (dichlorphenamide or Daranide?, methazolamide or Neptazane?), dorzolamide decreases aqueous humor production by the ciliary body epithelium by altering pH and affecting the H⁺/Na⁺ active transport exchange mechanism. Oral carbonic anhydrase inhibitors cause numerous systemic side effects such as metabolic acidosis and panting, diarrhea, vomiting, anorexia and others, all of which can be avoided with topical carbonic anhydrase inhibitors.

Dorzolamide Hydrochloride Upstream-Materialien And Downstream Produkte

Dorzolamide Hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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