2'-Iodoacetophenone

Bezeichnung:2'-Iodoacetophenone

CAS-Nr2142-70-3

Englisch Name:2'-Iodoacetophenone

CBNumberCB7291551

SummenformelC8H7IO

Molgewicht246.05

MOL-Datei2142-70-3.mol

2'-Iodoacetophenone physikalisch-chemischer Eigenschaften

Siedepunkt	139-140°C 12mm
Dichte	1.72 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.618(lit.)
Flammpunkt	218 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Aggregatzustand	Liquid
Wichte	1.720
Farbe	Clear yellow
Sensitive	Light Sensitive
BRN	2325078
CAS Datenbank	2142-70-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	36/38
S-Sätze:	26-36-24/25
WGK Germany	3
HazardClass	IRRITANT
HS Code	29147000

Gefahreninformationscode (GHS)

2'-Iodoacetophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Clear yellow liquid
Verwenden
2′-Iodoacetophenone (2-Iodoacetophenone) may be used in the synthesis of:
indene derivatives
di-(o-acetylphenyl)acetylene
indenol derivative
synthetische
2'-Iodoacetophenone can be synthesized by diazotization of 2-acetylaniline.
To a solution of p-TsOH (22.80 g, 120 mmol) in CH3CN (160 mL) was added an aromatic amine (40 mmol). The resulting amine salt suspension was cooled to 0-5°C. A solution of NaNO2 (5.52 g, 80 mmol) in H2O (12 mL) and KI (16.6 g, 100 mmol) in H2O (12 mL) were added sequentially. The reaction mixture was stirred for 10 minutes, then allowed to warm to ambient temperature and stirred until all the amine was consumed. To the reaction mixture were then added H2O (700 mL), NaHCO3 (1M; until pH=9-10) and Na2S2O3 (2M, 80 mL). The reaction mixture was extracted with EtOAc and purified by column chromatography (hexanes:EtOAc, 9:1 v/v) to give 2'-iodoacetophenone:yellow oil in 94% yield.
Reaktionen
2'-Iodoacetophenone is a bioactive molecule that reacts with boronic acids to form aryl boronic acid derivatives. This reaction can be carried out in chlorobenzene or dihedral solvents, and it is scalable and applicable to a variety of boronic acids. The product of this reaction is an organocatalyst for the synthesis of bioactive molecules. 2'-Iodoacetophenone also reacts with dipole-containing additives to form dichlorodiphenyldichloroethane, which has been used as a fungicide, insecticide, and herbicide.
Allgemeine Beschreibung
2′-Iodoacetophenone is a halogenated aromatic ketone.

2'-Iodoacetophenone Upstream-Materialien And Downstream Produkte

2'-Iodoacetophenone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2142-70-3, 2'-Iodoacetophenone Verwandte Suche:

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