1,2,3,4-Tetrahydrochinolin

Bezeichnung:1,2,3,4-Tetrahydrochinolin

CAS-Nr635-46-1

Englisch Name:1,2,3,4-Tetrahydroquinoline

CBNumberCB7286982

SummenformelC9H11N

Molgewicht133.19

MOL-Datei635-46-1.mol

Synonyma

1,2,3,4-Tetrahydrochinolin

1,2,3,4-Tetrahydrochinolin physikalisch-chemischer Eigenschaften

Schmelzpunkt	9-14 °C (lit.)
Siedepunkt	113-117 °C/10 mmHg (lit.) 249 °C (lit.)
Dichte	1.061 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.593(lit.)
Flammpunkt	213 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Aggregatzustand	Liquid
pka	5.09±0.20(Predicted)
Farbe	Clear pale yellow to yellow
Geruch (Odor)	at 1.00 % in dipropylene glycol. honey civet animal phenolic
PH	10-11 (111g/l, H2O, 20℃)(as an emulsion)
Geruchsart	animal
Wasserlöslichkeit	<1 g/L (20 ºC)
FreezingPoint	11.0 to 20.0 ℃
BRN	116149
LogP	2.290
CAS Datenbank	635-46-1(CAS DataBase Reference)
NIST chemische Informationen	Quinoline, 1,2,3,4-tetrahydro-(635-46-1)
EPA chemische Informationen	1,2,3,4-Tetrahydroquinoline (635-46-1)

Sicherheit

Kennzeichnung gefährlicher	Xi,T
R-Sätze:	36/37/38-45
S-Sätze:	26-36/37-36-45-53
WGK Germany	3
TSCA	Yes
HS Code	29334990

Gefahreninformationscode (GHS)

1,2,3,4-Tetrahydroquinoline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
clear pale yellow to yellow liquid
Verwenden
1,2,3,4-Tetrahydroquinoline is a reagent used in the synthesis of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamides displaying fungicidal activity.
Definition
ChEBI: A member of the class of quinolines that is the 1,2,3,4-tetrahydro derivative of quinoline.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 34, p. 3905, 1986 DOI: 10.1248/cpb.34.3905
Tetrahedron, 52, p. 1631, 1996 DOI: 10.1016/0040-4020(95)00991-4
Synthese
1,2,3,4-Tetrahydroquinoline is synthesised using quinoline N-oxide as a raw material by chemical reaction. The specific synthesis steps are as follows:
General procedure: In a 1.5 mL reaction vial, B(C6F5)3 (0.025 mmol, 5.0 mol %) was dissolved in chloroform (0.60 mL), towhich diethylsilane (1.75 mmol, 3.5 equiv) was added. After shaking briefly, quinolines (1a-p, 0.50 mmol, 1.0equiv) was subsequently added to the above catalyst solution under argon atmosphere. The reaction mixturewas stirred at 25-65 oC for 6-24 h for the reaction of 1a-h, and at 25-100 oC for 2-24 h for the reaction of 1i-p,then allowed to cool down to room temperature and concentrated under reduced pressure to give the crudeproduct. This reaction mixture was then treated with 0.25 N HCl ethereal solution (7 mL) and stirred at roomtemperature for 1 h to give the solid residue, which was subsequently washed with ether. The solid residue wasthen dissolved or suspended in MeOH (1.0 mL) and neutralized with Na₂CO₃·H₂O (0.5 g) at 0 oC. After stirringfor 2 h, MeOH was removed under reduced pressure, and the neutralized reaction residue was dissolved inCH₂Cl₂ and washed with brine (5 mL) and water (5 mL). The crude product was then obtained from the organicphase of CH₂Cl₂ solution and finally purified by column chromatography on silica gel to give 2a-h(EtOAc/Hexane = 1/9) and 2i-p (EtOAc/Hexane = 3/7).

1,2,3,4-Tetrahydroquinoline Upstream-Materialien And Downstream Produkte

1,2,3,4-Tetrahydrochinolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

635-46-1, 1,2,3,4-Tetrahydroquinoline Verwandte Suche:

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