Madecassic acid

Bezeichnung:Madecassic acid

CAS-Nr18449-41-7

Englisch Name:Madecassic acid

CBNumberCB7280283

SummenformelC30H48O6

Molgewicht504.71

MOL-Datei18449-41-7.mol

Madecassic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	270°C (dec.)
Siedepunkt	641.7±55.0 °C(Predicted)
Dichte	1.23±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO (Sparingly), Methanol (Slightly, Heated)
pka	4.63±0.70(Predicted)
Aggregatzustand	Solid
Farbe	White to Pale Red
InChIKey	PRAUVHZJPXOEIF-MRQYELSVNA-N
LogP	4.321 (est)

Sicherheit

Kennzeichnung gefährlicher	Xi
S-Sätze:	24/25
HS Code	29389090

Gefahreninformationscode (GHS)

Madecassic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Madecassic acid is a triterpenoid that has been found in C. asiatica and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E₂ (PGE₂; ), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages when used at a concentration of 150 μg/ml. Madecassic acid (0.05 and 0.1% in the diet) decreases plasma levels of fibrinogenin and triglycerides, as well as heart and kidney levels of reactive oxygen species (ROS), in a mouse model of diabetes induced by streptozotocin (STZ; ). It decreases tumor growth in a CT26 murine colon cancer model in a dose-dependent manner.
Chemische Eigenschaften
White powder
Verwenden
Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.
Verwenden
wound healing
Verwenden
Madecassic Acid is a terpenoid with an ursane skeleton isolated from Centella asiatica. Madecassic Acid displays anti-inflammatory properties as a result of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells. Madecassic Acid is found in cosmetic products due to its skin-protective activities.
Definition
ChEBI: A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3, 6 and 23 (the 2alpha,3beta,6beta stereoisomer).

Madecassic acid Upstream-Materialien And Downstream Produkte

Madecassic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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