5-Hydroxy-2-hydroxymethyl-4-pyron

Bezeichnung:5-Hydroxy-2-hydroxymethyl-4-pyron

CAS-Nr501-30-4

Englisch Name:Kojic acid

CBNumberCB7272507

SummenformelC6H6O4

Molgewicht142.11

MOL-Datei501-30-4.mol

Synonyma

5-Hydroxy-2-hydroxymethyl-4-pyron

5-Hydroxy-2-hydroxymethyl-4-pyron physikalisch-chemischer Eigenschaften

Schmelzpunkt	152-155 °C (lit.)
Siedepunkt	179.65°C (rough estimate)
Dichte	1.1712 (rough estimate)
Brechungsindex	1.4434 (estimate)
storage temp.	Store below +30°C.
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Sonicated)
Aggregatzustand	Crystalline Powder
pka	7.9(at 25℃)
Farbe	White to beige-brown
Wasserlöslichkeit	SOLUBLE
maximale Wellenlänge (λmax)	269nm(CHCl3)(lit.)
Merck	14,5317
BRN	120895
Stabilität	Stable. Combustible. Incompatible with strong oxidizing agents.
LogP	-0.640
CAS Datenbank	501-30-4(CAS DataBase Reference)
IARC	3 (Vol. 79) 2001
NIST chemische Informationen	5-Hydroxy-2-(hydroxymethyl)-4h-pyran-4-one(501-30-4)
EPA chemische Informationen	Kojic acid (501-30-4)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	40-68
S-Sätze:	22-24/25-36/37-36
WGK Germany	3
RTECS-Nr.	UQ0875000
HS Code	29329995
Giftige Stoffe Daten	501-30-4(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Kojic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
R68:Irreversibler Schaden möglich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
tan powder
Verwenden
Converted to maltol and ethyl maltol, flavor-enhancing additives. Food additive to inhibit tyrosinase.
Verwenden
hydroxystearate nonionic solubilizer
Verwenden
A naturally occurring chelation agent.
Verwenden
kojic acid is a skin-lightening agent that acts through anti-oxidant activity. Kojic acid is a tyrosinase inhibitor, although it is not as effective as licorice extract. When combined with allantoin and other proper ingredients in sunscreen preparations, the mixture can inhibit uV-caused erythema and accelerate wound healing. It is also found to be skin sensitizing and can be irritating.
Definition
ChEBI: A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae.
Allgemeine Beschreibung
Kojic acid, a tyrosinase inhibitor, is produced by several fungi species, including Aspergillus oryzae. It exhibits skin-lightening property, due to its ability to chelate the copper-containing enzyme tyrosinase in the formation of melanin. Kojic acid is also commonly used as a whitening agent in regular cosmetics, bleaching cosmetics, etc. It is found to be a therapeutic agent and helps in preventing pigmentation.
Biochem/physiol Actions
Kojic acid is derived from some fungal species such as, Aspergillus, Acetobacter and Penicillium.. It halts melanin synthesis by inhibiting tyrosinase enzyme. It is used in the preparation of skin whitening cosmetics. However, kojic acid usage is minimal in cosmetics, as it induces skin irritation by its unstability and cytotoxic nature during long storage. It is an antioxidant and elicits radioprotective effects on chelating with manganese and zinc.
läuterung methode
Crystallise the acid from MeOH (charcoal) by adding Et2O. It sublimes at 150-200o/0.1torr. [Beilstein 18 II 57, 18 III/IV 1145, 18/2 V 516.]

Kojic acid Upstream-Materialien And Downstream Produkte

5-Hydroxy-2-hydroxymethyl-4-pyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

501-30-4, Kojic acid Verwandte Suche:

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