Δ17-U-46619

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Δ17-U-46619 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  U-46619 is the consensus stable analog of prostaglandin H₂/thromboxane A₂ (PGH₂/TXA₂) and has been used as a TXA₂ agonist in pharmacologic studies for several decades.¹ There have been several hypotheses put forward by scientists studying ω-3 fatty acids stipulating that the agonist activity of TXA₃ was substantially different than that of TXA₂.² However, no stable analogs of TXA₃ were available to test these theories. Δ¹⁷-U-46619 is the first direct, stable analog of TXA₃ ever synthesized. There are no published reports on its activity to date.

• Einzelnachweise

  1. Bundy, G.L. The synthesis of prostaglandin endoperoxide analogs Tetrahedron Lett. 24,1957-1960(1975).
  2. Parent, C.A., Lagarde, M., Venton, D.L., et al. Selective modulation of the human platelet thromboxane A₂/prostaglandin H₂ receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes J. Biol. Chem. 267,6541-6547(1992).

Δ17-U-46619 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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