(S)-MEPHENYTOIN Struktur

(S)-MEPHENYTOIN

Bezeichnung:(S)-MEPHENYTOIN

CAS-Nr70989-04-7

Englisch Name:(S)-MEPHENYTOIN

CBNumberCB7257425

SummenformelC12H14N2O2

Molgewicht218.25

MOL-Datei70989-04-7.mol

(S)-MEPHENYTOIN physikalisch-chemischer Eigenschaften

Schmelzpunkt	135-138 °C
Dichte	1.154±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: soluble
Aggregatzustand	solid
pka	8.07±0.70(Predicted)
Farbe	off-white

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	2
HS Code	29332100

Gefahreninformationscode (GHS)

(S)-MEPHENYTOIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
S-Mephenytoin has been used as a CYP2C19 substrate for the analysis of cytochrome P450 metabolism. S-Mephenytoin has also been used as probe substrates for LC/MS-based analysis of relative activity factor (RAF).
Verwenden
(S)-Mephenytoin can be used as an anticonvulsant agent.
Definition
ChEBI: (S)-Mephenytoin is an imidazolidine-2,4-dione.
Biologische Aktivität
(s)-mephenytoin is an anticonvulsive drug which is metabolized by n-demethylation and 4-hydroxylation (of the aromatic ring). (s)-mephenytoin is a substrate of the cytochrome p450 (cyp) isoform cyp2c19, also known as mephenytoin 4-hydroxylase [1].cyp2c19 is the main mephenytoin 4-hydroxylase in humans implicated in metabolizing a variety of therapeutic agents, such as omeprazole, proguanil, diazepam, propranolol, citalopram, imipramine, and certain barbiturates [2].
Biochem/physiol Actions
CYP2B6 & CYP2C19 substrate. Methenytoin isomer. Anticonvulsant; antiepileptic.
in vitro
in the presence of cytochrome b5, the km value for s-mephenytoin was 1.25 mm with all five purified cytochrome p-450s preparations, and vmax values were 0.8-1.25 nmol of 4-hydroxy product formed per min/nmol of p-450 [1].
Einzelnachweise
[1] shimada t, misono k s, guengerich f p. human liver microsomal cytochrome p-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. purification and characterization of two similar forms involved in the reaction[j]. journal of biological chemistry, 1986, 261(2): 909-921.
[2] ferguson r j, de morais s m f, benhamou s, et al. a new genetic defect in human cyp2c19: mutation of the initiation codon is responsible for poor metabolism of s-mephenytoin[j]. journal of pharmacology and experimental therapeutics, 1998, 284(1): 356-361.

(S)-MEPHENYTOIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

70989-04-7, (S)-MEPHENYTOIN Verwandte Suche:

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