3-Amino-4-methoxybenzanilid

Bezeichnung:3-Amino-4-methoxybenzanilid

CAS-Nr120-35-4

Englisch Name:3-Amino-4-methoxybenzanilide

CBNumberCB7251074

SummenformelC14H14N2O2

Molgewicht242.27

MOL-Datei120-35-4.mol

Synonyma

3-Amino-4-methoxybenzanilid

3-Amino-4-methoxybenzanilid physikalisch-chemischer Eigenschaften

Schmelzpunkt	154-156°C
Siedepunkt	385.1°C (rough estimate)
Dichte	1.1338 (rough estimate)
Dampfdruck	0-0Pa at 25℃
Brechungsindex	1.6419 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	13.44±0.70(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
LogP	2.08 at 23℃ and pH7
CAS Datenbank	120-35-4(CAS DataBase Reference)
EPA chemische Informationen	Benzamide, 3-amino-4-methoxy-N-phenyl- (120-35-4)

Sicherheit

R-Sätze:	36/37/38
S-Sätze:	26-36/37/39
RTECS-Nr.	CV7400000
TSCA	Yes
HazardClass	IRRITANT
HS Code	2924297099
Toxizität	mouse,LD50,intravenous,320mg/kg (320mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01183,

Gefahreninformationscode (GHS)

3-Amino-4-methoxybenzanilide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Gray powder.
Verwenden
3-Amino-4-methoxybenzanilide is used in preparation method of Cyanate resin-based near-zero expansion composite material truss rod.
Verwenden
Dyes, pharmaceuticals, and other organic chemicals.
Synthese
3-Amino-4-methoxybenzanilide is prepared by the reaction of 3-amino-4-methoxybenzoic acid and aniline. The steps are as follows:
A total of 0.17 mL (0.18 mmol) of DIC and 0.24 g (0.18 mmol) of HOBt were added to a dichloromethane solution of 0.20 g (0.12 mmol) of 1 at room temperature, and the reaction mixture was stirred for 0.5 h. Then, 0.13 mL (0.14 mmol) of aniline was added to the mixture. After approximately 3 h, 0.5 N NaOH was added to the solution. The lower layer was isolated, and 0.5 N HCl was added until the aqueous solution was neutral. The dichloromethane layer was washed three times with 10 mL of water, and then MgSO4 was added. After 2 h, the solution was filtered, and the solvent was removed. The residue was purified by column chromatography on silica gel (eluent: petroleum ether:ethyl acetate = 3:1) to yield the desired 3-Amino-4-methoxybenzanilide as a white solid (yield: 76%). Mp: 197-198 °C. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 9.92 (1H, s, NH), 7.74 (2H, d, J = 9.0 Hz, PhH), 7.32 (2H, m, PhH), 7.21 (2H, d, J = 8.0 Hz, PhH), 7.06 (1H, m, PhH), 6.88 (1H, d, J = 8.0 Hz, PhH), 4.90 (2H, br s, NH2), 3.83 (3H, s, OCH3). ESI-MS (m/z): 243 (M + H)+.

3-Amino-4-methoxybenzanilide Upstream-Materialien And Downstream Produkte

3-Amino-4-methoxybenzanilid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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