Hydromorphonhydrochlorid

Bezeichnung:Hydromorphonhydrochlorid

CAS-Nr71-68-1

Englisch Name:Hydromorphone hydrochloride

CBNumberCB7250921

SummenformelC17H20ClNO3

Molgewicht321.8

MOL-Datei71-68-1.mol

Synonyma

Hydromorphonhydrochlorid

Hydromorphonhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	>280°C (dec.)
alpha	D25 -133°
Dichte	1.1451 (rough estimate)
Brechungsindex	1.6470 (estimate)
storage temp.	2-8°C
Löslichkeit	H₂O: >10 mg/mL
Aggregatzustand	A crystalline solid
EPA chemische Informationen	Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, hydrochloride (1:1), (5.alpha.) (71-68-1)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	16-36/37-45
RIDADR	UN 1230 3/PG 2
WGK Germany	3
RTECS-Nr.	QD2625000
HazardClass	6.1(a)
PackingGroup	II
HS Code	2939110000
Toxizität	LD50 in mice (mg/kg): 61-96 i.v. (Buchwald, Eadie)

Gefahreninformationscode (GHS)

Hydromorphone hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Hydromorphone hydrochloride is a pure opioid agonist with the principal therapeutic activity of analgesia. It has an analgesic potency approximately two to eight times greater than that of morphine and has a rapid onset of action. A significant feature of the analgesia is that it can occur without loss of consciousness.
Chemische Eigenschaften
White Solid
Verwenden
Analgesic (narcotic). Preparation by electrolytic reduction of Morphine. Controlled substance (opiate).
Biochem/physiol Actions
Narcotic opiate analgesic; μ opioid receptor agonist.
Clinical Use
Hydromorphone is a potent μ agonist (eight times greater than morphine) that is used to treat severe pain. It is available in intramuscular, intravenous, subcutaneous, oral, and rectal dosage forms. Like all strong μ agonists, hydromorphone is addicting and is a Schedule II drug. Hydromorphone has an oral:parenteral potency ratio of 5:1. The plasma half-lives after parenteral and oral dosage are 2.5 and 4 hours, respectively.
Sicherheitsprofil
Poison by subcutaneous and intravenous routes. Experimental teratogenic effects. A powerful analgesic. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also MORPHINE.
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Alcohol: can cause dose dumping with sustained release preparations.
Analgesics: possible opioid withdrawal effects with buprenorphine and pentazocine.
Antidepressants: possible CNS excitation or depression with MAOIs - avoid concomitant use and for 2 weeks after stopping MAOI; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate - avoid.
Stoffwechsel
Hydromorphone undergoes extensive firstpass metabolism. It is extensively metabolised by glucuronidation in the liver and excreted in the urine mainly as conjugated hydromorphone, dihydroisomorphine, and dihydromorphine.

Hydromorphone hydrochloride Upstream-Materialien And Downstream Produkte

Hydromorphonhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

71-68-1, Hydromorphone hydrochloride Verwandte Suche:

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