Hydromorphonhydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H336：Kann Schläfrigkeit und Benommenheit verursachen.

Hydromorphone hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.

• S-Sätze Betriebsanweisung:

  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

• Beschreibung

  Hydromorphone hydrochloride is a pure opioid agonist with the principal therapeutic activity of analgesia. It has an analgesic potency approximately two to eight times greater than that of morphine and has a rapid onset of action. A significant feature of the analgesia is that it can occur without loss of consciousness.

• Chemische Eigenschaften

  White Solid

• Verwenden

  Analgesic (narcotic). Preparation by electrolytic reduction of Morphine. Controlled substance (opiate).

• Biochem/physiol Actions

  Narcotic opiate analgesic; μ opioid receptor agonist.

• Clinical Use

  Hydromorphone is a potent μ agonist (eight times greater than morphine) that is used to treat severe pain. It is available in intramuscular, intravenous, subcutaneous, oral, and rectal dosage forms. Like all strong μ agonists, hydromorphone is addicting and is a Schedule II drug. Hydromorphone has an oral:parenteral potency ratio of 5:1. The plasma half-lives after parenteral and oral dosage are 2.5 and 4 hours, respectively.

• Sicherheitsprofil

  Poison by subcutaneous and intravenous routes. Experimental teratogenic effects. A powerful analgesic. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also MORPHINE.

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Alcohol: can cause dose dumping with sustained release preparations.
  Analgesics: possible opioid withdrawal effects with buprenorphine and pentazocine.
  Antidepressants: possible CNS excitation or depression with MAOIs - avoid concomitant use and for 2 weeks after stopping MAOI; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics.
  Antihistamines: increased sedative effects with sedating antihistamines.
  Antipsychotics: enhanced hypotensive and sedative effects.
  Dopaminergics: avoid with selegiline.
  Nalmefene: avoid concomitant use.
  Sodium oxybate: enhanced effect of sodium oxybate - avoid.

• Stoffwechsel

  Hydromorphone undergoes extensive firstpass metabolism. It is extensively metabolised by glucuronidation in the liver and excreted in the urine mainly as conjugated hydromorphone, dihydroisomorphine, and dihydromorphine.

Hydromorphone hydrochloride Upstream-Materialien And Downstream Produkte

Hydromorphonhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(50)Suppliers

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