PD 153035 HYDROCHLORIDE Struktur

PD 153035 HYDROCHLORIDE

Bezeichnung:PD 153035 HYDROCHLORIDE

CAS-Nr153436-54-5

Englisch Name:PD 153035 HYDROCHLORIDE

CBNumberCB7249204

SummenformelC16H14BrN3O2

Molgewicht360.21

MOL-Datei153436-54-5.mol

PD 153035 HYDROCHLORIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	189-190 °C
Siedepunkt	472.1±45.0 °C(Predicted)
Dichte	1.499±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	Soluble in DMSO (up to 5 mg/ml).
pka	5.55±0.30(Predicted)
Aggregatzustand	White to off-white solid.
Farbe	White or off-white
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Gefahreninformationscode (GHS)

PD 153035 HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.1?Inhibits the growth of a number of cancer cell lines.2?AG-1517 HCl is an extremely useful tool for exploring EGF-mediated cellular signaling.3
Chemische Eigenschaften
Yellowish solid
Verwenden
PD 153035 is an extremely potent and specific inhibitor of EGFR tyrosine kinase activity.
Verwenden
PD153035 is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM).
Definition
ChEBI: A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.
Biologische Aktivität
An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC 50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.
target
EGFR
Einzelnachweise
1) Fry et al. (1994), A specific inhibitor of the epidermal growth factor receptor tyrosine kinase; Science, 265 1093 2) Bos et al. (1997), PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner; Clin. Cancer Res., 3 2099 3) Tetreault et al. (2008), Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayers; J. Cell. Biochem., 105 1240

PD 153035 HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

PD 153035 HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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