4-Hydroxy Cholesterol-d7

4-Hydroxy Cholesterol-d7 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

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• Verwenden

  4β-Hydroxy Cholesterol-d7 is a labelled metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.

• Verwenden

  4β-hydroxycholesterol-d7 has been used:
  
  • as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
  • to spike serum samples for mass spectrometry measurements
  • as an internal standard for the quantification of human colon biopsies samples using HPLC-MS
  
  

• Allgemeine Beschreibung

  4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol.

• Biochem/physiol Actions

  4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand. The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation.

4-Hydroxy Cholesterol-d7 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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