SC 57461A

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

• Sicherheit

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

SC 57461A Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Leukotriene A₄ (LTA₄) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB₄ from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA₄ hydrolase that blocks ionophore-stimulated LTB₄ synthesis in whole blood (IC₅₀ = 49 nM). It blocks both the hydrolase and aminopeptidase activity in vitro. SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC₄ synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB₄ biosynthesis without affecting LTC₄ or 6-keto prostaglandin F_1α production . Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice.

• Chemische Eigenschaften

  White Solid

• Verwenden

  A potent and selective orally active leukotriene A4 hydrolase inhibitor.

• Verwenden

  SC 57461A is a potent and selective inhibitor of LTA4.

• Biologische Aktivität

  Potent and selective inhibitor of LTA 4 hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC 4 synthase and 5-lipoxygenase. Potently inhibits LTB 4 production in whole blood (IC 50 = 49 nM). Orally active.

SC 57461A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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