21-Ethyl-4-methyl-16-methylene-7,20-cycloveatchane-1α,12α,15β-triol 15-acetate

21-Ethyl-4-methyl-16-methylene-7,20-cycloveatchane-1α,12α,15β-triol 15-acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  This atisine alkaloid, obtained from Aconitum lucidusculum and A. yeosoensis, was originally given the empirical formula C24H3704N, later changed to that given above. The base crystallizes in colourless leaflets from MeOH and has [α]_D- 95.5° (CHCI3). All of the salts crystallize well: the hydrochloride monohydrate, m.p. 98-115°C or 245-265°C (dry, dec.); the hydrobromide, m.p. 248-2500C; [α]²⁰_D - 62.7° (H20); the hydriodide as orthorhombic crystals, m.p. 249-2500C; perchlorate decomposing at 260-5°C; [α]¹⁵_D - 70.3° (EtOH); methiodide, m.p. 197°C; [α]¹⁵_D - 65° (EtOH) and the picrate, m.p. 173-6°C. The alkaloid contains a secondary and a tertiary hydroxyl group and forms the monoacetate as the crystalline trihydrate, m.p. 113-7°C or 139-144°C (dry); [α]¹⁵_D- 50.4° (H20). On alkaline hydrolysis, the alkaloid yields acetic acid and Luciduline (q.v.).

• Einzelnachweise

  Majima, Morio.,Proc. Imp. Acad. Tokyo, 7,351 (1931)
  Majima, Morio., Ber., 65, 599 (1932)
  Suginome, Amiya, Shima., Bull. Chem. Soc., Japan, 32, 824 (1959) V Crystal structure:
  Yoshino, Iitaka., Acta Cryst., 21,57 (1966)