2-Methyl-5-nitrobenzolamin

Bezeichnung:2-Methyl-5-nitrobenzolamin

CAS-Nr99-55-8

Englisch Name:2-Methyl-5-nitroaniline

CBNumberCB7234387

SummenformelC7H8N2O2

Molgewicht152.15

MOL-Datei99-55-8.mol

Synonyma

5-Nitro-o-toluidin

2-Methyl-5-nitrobenzolamin

2-Methyl-5-nitrobenzolamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	103-106 °C(lit.)
Siedepunkt	294.61°C (rough estimate)
Dichte	1.2333 (estimate)
Brechungsindex	1.6276 (estimate)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Crystalline Powder
pka	2.34±0.10(Predicted)
Farbe	Ochre to yellow-orange
Wasserlöslichkeit	<0.1 g/100 mL at 19 ºC
BRN	879021
Expositionsgrenzwerte	ACGIH: TWA 1 mg/m3
Stabilität	Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids, chloroformates.
CAS Datenbank	99-55-8(CAS DataBase Reference)
IARC	3 (Vol. 48) 1990
NIST chemische Informationen	Benzenamine, 2-methyl-5-nitro-(99-55-8)
EPA chemische Informationen	2-Methyl-5-nitroaniline (99-55-8)

Sicherheit

Kennzeichnung gefährlicher	T,Xi
R-Sätze:	23/24/25-40-52/53
S-Sätze:	36/37-45-61
RIDADR	UN 2660 6.1/PG 3
WGK Germany	3
RTECS-Nr.	XU8225000
Hazard Note	Irritant
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29214300
Giftige Stoffe Daten	99-55-8(Hazardous Substances Data)
Toxizität	LD50 orl-rat: 574 mg/kg NCIMR* NIH-71-E-2144,73

Gefahreninformationscode (GHS)

2-Methyl-5-nitroaniline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
2-Methyl-5-nitroaniline, also known as 5-nitro-o-toluidine, is an intermediate compound in the synthesis of a wide range of azo dyes and is an in vivo metabolic product of 2,4-dinitrotoluene.
Chemische Eigenschaften
5-Nitro-o-toluidine is a yellow, crystalline solid.
Verwenden
5-Nitro-o-toluidine is used in the synthesis of numerous dyes.
Verwenden
2-Methyl-5-nitroaniline may be employed as analytical standard for the surfactant mediated transformations (?254nm) of 2,4-dinitrotoluene.
synthetische
o-Toluidine(500 mg, 4.19 mmol) was added with vigorous stirring to a balloon with concentrated sulfuric acid (3.9 ml, 71.4 mmol). The temperature of the reaction is 10 ℃ (salt/ice, cold bath). After that, an acid mixture (0.9 mlHNO3 and 0.9 ml H2SO4) was added to the solution for 2 h. The mixture was placed on ice and basified with NaOH. Finally, 2-methyl-5-nitroaniline was collected by filtration and washed with water.
Definition
ChEBI: A C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine.
synthetische
2-Methyl-5-nitrobenzenamine?in concentrated sulfuric acid nitration.
Air & Water Reaktionen
Insoluble in water. 2-Methyl-5-nitroaniline is sensitive to moisture, light, or prolonged exposure to air.
Reaktivität anzeigen
2-Methyl-5-nitroaniline is incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides and chloroformates.
Brandgefahr
Flash point data for 2-Methyl-5-nitroaniline are not available; however, 2-Methyl-5-nitroaniline is probably combustible.
Toxikologie
Genetic toxicity studies for 2-methyl-5-nitroaniline indicate generally positive results in reverse-mutation assays in Salmonella typhimurium and Escherichia coli, and in Syrian hamster embryo (SHE) cell transformation assays; the compound is weaker in potency than other 2,4-dinitrotoluene metabolites.
Sicherheitsprofil
Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion. Mutation data reported. Decomposes exothermically when heated to 150℃. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.
Carcinogenicity
There are no data available for evaluating carcinogenic risk to humans. When 5-nitro-o-toluidine was administered in a dietary feeding study to F344 rats (50 or 100 ppm) and B6C3F1 mice (1200 or 2300 ppm) of both sexes, hepatocellular carcinomas were produced in mice but not in rats.
Versand/Shipping
UN2660 Nitrotoluidines (mono), Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
läuterung methode
Acetylate the aniline, and the acetyl derivative is crystallised to constant melting point; then hydrolyse it with 70% H2SO4 and the free base is regenerated by treatment with NH3 [Bevan et al. J Chem Soc 4284 1956]. [Beilstein 12 H 844. 12 IV 1807.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides; chloroformates.
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

2-Methyl-5-nitroaniline Upstream-Materialien And Downstream Produkte

2-Methyl-5-nitrobenzolamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

99-55-8, 2-Methyl-5-nitroaniline Verwandte Suche:

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